Research Insights About Covid-19
We attempt to provide selected highlights in recent research findings
Last Update on 6 September 2020
A. Medicine and Health
September 4, 2020 (The Lancet)
Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial
Remo H M Furtado, Otavio Berwanger, Henrique A Fonseca et al.
The authors performed an open-label multicentre randomised control trial to assess whether adding azithromycin to the standard of care, which included hydroxychloroquine, would improve clinical outcomes of patients admitted to the hospital with severe COVID-19. They found that the addition of azithromycin did not improve clinical outcomes.
September 4, 2020 (The Lancet)
Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia
Denis Y Logunov, Inna V Dolzhikova, Olga V Zubkova et al.
Logunov and his team assessed the safety and immunogenicity of a heterologous COVID-19 vaccine that they had developed. The vaccine consists of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector, both carrying the gene for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (rAd26-S and rAd5-S). They assessed the safety and immunogenicity of two formulations (frozen and lyophilised) of this vaccine and found that the vaccine not only has a good safety profile but also induced strong humoral and cellular immune responses in participants.
September 4, 2020 (Nature Reviews Immunology)
Immunological considerations for COVID-19 vaccine strategies
Jeyanathan, M., Afkhami, S., Smaill, F. et al.
Jeyanathan et al. discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. Based on these principles, they examine the current COVID-19 vaccine candidates, their strengths and potential shortfalls, and make inferences about their chances of success. Finally, they discuss the scientific and practical challenges that will be faced in the process of developing a successful vaccine and how COVID-19 vaccine strategies may evolve over the next few years.
September 2, 2020 (NEJM)
Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine
Cheryl Keech, Gary Albert, Iksung Cho et al.
This randomized, placebo-controlled, phase 1–2 trial was carried out to evaluate the safety and immunogenicity of the SARS-CoV-2 vaccine. A recombinant SARS-CoV-2 spike protein nanoparticle vaccine delivered in the deltoid muscle on days 0 and 21 was found to be immunogenic at both 5 μg and 25 μg doses. When given with a saponin-based adjuvant, both doses were equally immunogenic, with little or no reactogenicity, and elicited neutralizing antibody titers higher than those in convalescent serum.
September 2, 2020 (JAMA)
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis
The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group
In this prospective meta-analysis of 7 randomized trials that included 1703 patients of whom 647 died, 28-day all-cause mortality was lower among patients who received corticosteroids compared with those who received usual care or placebo showing that administration of systemic corticosteroids, compared with usual care or placebo, was associated with lower 28-day all-cause mortality in critically ill patients with COVID-19.
September 1, 2020 (NEJM)
Humoral Immune Response to SARS-CoV-2 in Iceland
Daniel F. Gudbjartsson, Gudmundur L. Norddahl, Pall Melsted et al.
This large comparative study of the Icelandic population showed that the humoral response did not decline within 4 months after infection, that 44% of persons who had been infected had not been diagnosed with qPCR, and that the infection fatality risk was 0.3%.
September 1, 2020 (The Lancet Inf. Diseases)
Long-term consequences of COVID-19: research needs
Dana Yelin, Eytan Wirtheim, Pauline Vetter et al.
In this commentary, Yelin et al. emphasize the need to perform research assessing the long-term sequelae of COVID-19. They also raise questions that need to be answered to provide patients and health-care workers with a better understanding of the course and prognosis of this disease.
July 31, 2020 (Diagnostics)
Effect of Coronavirus Disease 2019 in Pulmonary Circulation. The Particular Scenario of Precapillary Pulmonary Hypertension
Jorge Nuche, Teresa Segura de la Cal, Carmen Jimenez Lopez Guarch et al.
Patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) could represent an especially vulnerable population for developing severe COVID-19 because of the high mortality rates reported for respiratory infections. However, the number of cases reported among PAH and CTEPH patients is surprisingly low. Endothelial dysfunction is a common feature between patients with PAH/CTEPH and COVID-19, leading to ventilation/perfusion mismatch, vasoconstriction, thrombosis and inflammation. In this comprehensive review, the authors describe the similarities and differences between both conditions and the possible pathophysiological and therapeutic-based mechanisms leading to the low incidence and severity of COVID-19 reported in PAH/CTEPH patients to date.
July 30, 2020 (Infection)
Prognostic value of serum amyloid A in patients with COVID-19
Li Cheng, Jian-Zhong Yang, Wen-Hui Bai et al.
The authors investigated the prognostic value of serum Amyloid A (SAA) in patients with laboratory confirmed COVID-19 patients. They collected data from 89 patients and divided them into survival group and non-survival group. The SAA levels of all patients were recorded and compared on 1 day after admission (before treatment) and 3 days, 5 days, and 7 days after treatment. They found that SAA can be used as a predictor of the prognosis in patients with COVID-19.
July 29, 2020 (JAMA Network Open)
Comparison of Face-Touching Behaviors Before and During the Coronavirus Disease 2019 Pandemic
Yong-Jian chen, Gang Qin, Jie Chen et al.
his cross-sectional study examines mask wearing and face-touching behaviors before and during the coronavirus disease 2019 (COVID-19) pandemic in China, Japan, South Korea, Western Europe, and the US.
July 28, 2020 (Infection)
Pulmonary function in patients surviving to COVID-19 pneumonia
Alessia Fumagalli, Clementina Misuraca, Achille Bianchi et al.
The authors studied the respiratory function of 13 confirmed COVID-19 patients at the time of clinical recovery and 6 weeks after discharge in patients surviving to COVID-19 pneumonia. They found that patients with COVID-19 pneumonia may have clinically relevant alterations in pulmonary function tests, with a mainly restrictive pattern.
July 28, 2020 (Infection)
Cardiac manifestations of COVID-19 in Shenzen, China
Jia-Hui Zeng, Wei-Bo Wu, Jiu-Xin Qu et al.
The authors compared clinical and echocardiographic characteristics of 416 confirmed COVID-19 inpatients in the intensive care unit (ICU) and non-ICU patients. They found that myocardial injury marker elevation, ventricular wall thickening, pulmonary artery hypertension, and cardiac complications including acute myocardial injury, arrhythmia, and acute heart failure are more common in ICU patients with COVID-19. Cardiac injury in COVID-19 patients may be related more to the systemic response after infection rather than direct damage by coronavirus.
July 28, 2020 (NEJM)
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Kizzmekia S. Corbett, Barbara Flynn, Kathryn E. Foulds et al.
Two injections of an mRNA-based vaccine encoding the SARS-CoV2 spike protein elicited high levels of neutralizing antibody and Th1 CD4 T-cell responses in rhesus macaques. Two days after challenge of vaccinated animals with intranasal and intratracheal virus, viral replication was undetectable in bronchoalveolar-lavage fluid and nasal secretions.
July 27, 2020 (JAMA Network Open)
Estimation of Viral Aerosol Emissions From Simulated Individuals with Asymptomatic to Moderate Coronavirus Disease 2019
Michael Riediker, Dai-Hua Tsai
This mathematical modeling study estimates viral aerosol emissions from simulated individuals with asymptomatic to moderate coronavirus disease 2019 (COVID-19).
July 27, 2020 (Nature)
Longitudinal analyses reveal immunological misfiring in severe COVID-19
Lucas, C., Wong, P., Klein, J. et al.
The authors serially analysed immune responses in 113 COVID-19 patients with moderate (non-ICU) and severe (ICU) disease. Immune profiling revealed an overall increase in innate cell lineages with a concomitant reduction in T cell number. The authors identified development of a maladapted immune response profile associated with severe COVID-19 outcome and early immune signatures that correlate with divergent disease trajectories.
July 24, 2020 (Science)
The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries
Patrick G. T. Walker, Charles Whittaker, Oliver J. Watson et al.
The authors combine data on demography, contact patterns, disease severity and health care capacity and quality to understand the impact of COVID-19 and inform strategies for its control.
July 24, 2020 (JAMA)
Presence of Genetic Variants Among Young Men With Severe COVID-19
Caspar I. van der Made, Annet Simmons, Janneke Schuurs-Hoeijmakers et al.
This case series included 4 young male patients, with no previous medical ailments who were admitted with severe COVID-19 from 2 families (2 pairs of brothers). The authors performed rapid clinical whole-exome sequencing, as well as basic genetic and immunological tests in primary immune cells isolated from the patients and family members to characterize any immune defects. They found rare loss-of- function variants of the X-chromosomal TLR7, with immunological defects in type I and II interferon production. These preliminary findings provide insights into the pathogenesis of COVID-19.
July 24, 2020 (JAMA)
Molecular Underpinnings of Severe Coronavirus Disease 2019
Robert M. Plenge
The molecular underpinnings of the SARS-CoV-2 infection and the COVID-19 disease it causes are poorly understood. Inherited genetic variation is an important tool to disentangle cause and consequence, which in turn can generate insights to guide therapeutic interventions to prevent or treat disease. The author reviews the study by van der Made and colleagues (above) and discusses the diagnostic and therapeutic implications of this genetic study for SARS-CoV-2 and COVID-19? The author concludes that the genetic study begins to unravel the molecular underpinnings of COVID-19, and as additional genetic loci are identified, such data could lead to improved diagnostics and therapeutics, including rational repurposing of existing anti-inflammatory therapies in either early infection or late-stage severe disease.
July 23, 2020 (NEJM)
Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
Leora R Feldstein, Erica B. Rose, Steven M. Horwitz et al.
This report describes the epidemiology and clinical course of patients younger than 21 years of age from 26 states in USA who had multisystem inflammatory syndrome. Many were infected with SARS-CoV2 at least 1 – 2 weeks before syndrome onset. The median age of the patients was 8.3 years, and 73% were previously healthy.
July 22, 2020 (JAMA)
Pooling Data from Individual Clinical Trials in the COVID-19 Era
Eva Petkova, Elliot M. Antman, Andrea B. Troxel
This Viewpoint proposes principles and processes to allow pooling of individual patient data from clinical trials given decelerating participant recruitment at sites where the COVID-19 surge has been controlled and new cases are diminishing.
July 21, 2020 (Jama Int Med)
Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020
Fiona P. Havers, Carrie Reed, Travis Lim et al.
This cross-sectional study estimates the prevalence of severe acute respiratory syndrome coronavirus 2 antibodies in convenience samples from 10 geographic sites in the United States. Of the 16025 clinical specimens tested, it was estimated that the proportion of persons with detectable SARS-CoV-2 antibodies ranged from 1.0% in the San Francisco Bay area (collected April 23-27) to 6.9% of persons in New York City (collected March 23-April 1). Six to 24 times more infections were estimated per site with seroprevalence than with coronavirus disease 2019 (COVID- 19) case report data. The results indicate that it is likely that greater than 10 times more SARS-CoV-2 infections occurred than the number of reported COVID-19 cases; most persons in each site, however, likely had no detectable SARS-CoV-2 antibodies.
July 21, 2020 (JAMA)
Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV2
Elizabeth Whittaker, Alasdair Bamford, Julia Kenny et al.
This case series describes the clinical and laboratory characteristics of children hospitalized in England from March to May 2020 who met criteria for pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS), and compares syndrome characteristics with historical cases of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome (TSS).
July 20, 2020 (The Lancet)
Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomized, double-blind, placebo-controlled, phase 2 trial
Feng-Cai Zhu, Xu-Hua Guan, Yu-Hua Li et al.
This authors report the results of the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine. The trial was aimed at determining an appropriate dose of the candidate vaccine for an efficacy study. The authors found that the Ad5-vectored COVID-19 vaccine at 5 × 1010 viral particles is safe, and induced significant immune responses in the majority of recipients after a single immunisation.
July 20, 2020 (The Lancet)
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1 / 2, single-blind, randomised controlled trial
Pedro M Folegatti, Katie J Ewer, Parvinder K Aley et al.
The authors assessed the safety, reactogenicity, and immunogenicity of a viral vectored coronavirus vaccine that expresses the spike protein of SARS-CoV-2. ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. These results, together with the induction of both humoral and cellular immune responses, support large-scale evaluation of this candidate vaccine in an ongoing phase 3 programme.
July 20, 2020 (JAMA)
Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System
Seda Bilaloglu, Yin Aphinyanaphongs, Simon Jones, et al.
This study examines the incidence of and risk factors for venous and arterial thrombosis in patients hospitalized with COVID-19 in 4 New York City hospitals.
July 18, 2020 (European Radiology)
From community-acquired pneumonia to COVID-19: a deep learning–based method for quantitative analysis of COVID-19 on thick-section CT scans
Zhang Li, Zheng Zhong, Yang Li et al.
In this retrospective study, an AI system was developed to automatically segment and quantify the COVID-19 infected lung regions on thick-section chest CT images. The authors found that this system can accurately quantify the COVID-19-associated lung abnormalities and assess the disease severity and its progressions.
July 17, 2020 (Science)
Aging immunity may exacerbate COVID-19
Arne N. Akbar and Derek W. Gilroy
This Viewpoint piece describes the immune system in the elderly population and how it contributes to florid inflammation seen in more severe manifestation of Covid-19 infections among the aged.
July 17, 2020 (The NEJM)
Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
The RECOVERY Collaborative Group
This preliminary report by the RECOVERY Collaborative Group provides details on the current findings of the trial that looks at Dexamethasone in hospitalized Covid-19 patients, with 28-day mortality as a primary outcome.
July 15, 2020 (Nature Microbiology)
A dynamic nomenclature proposal for SARS-CoV2 lineages to assist genomic epidemiology
Andrew Rambaut, Edward C. Holmes, Aine O’Toole et al.
The ongoing pandemic spread of SARS-CoV-2, which is associated with severe pneumonia/disease (COVID-19), has resulted in the generation of tens of thousands of virus genome sequences. The rate of genome generation is unprecedented, yet there is currently no coherent nor accepted scheme for naming the expanding phylogenetic diversity of SARS-CoV-2. Here, the authors present a rational and dynamic virus nomenclature that uses a phylogenetic framework to identify those lineages that contribute most to active spread. Their system on active virus lineages and those spreading to new locations. This nomenclature will assist in tracking and understanding the patterns and determinants of the global spread of SARS-CoV-2.
July 15, 2020 (JAMA Psychiatry)
Meeting Maternal Mental Health Needs During the COVID-19 Pandemic
Alison Hermann, Elizabeth M. Fitelson, Veerle Bergink
This Viewpoint discusses current mental health concerns for pregnant and postpartum women in light of the coronavirus disease 2019 pandemic.
July 15, 2020 (JAMA Int. Med)
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
Shruti Gupta, Salim S. Hayek, Wei Wang, et al.
This cohort study of adults with COVID-19 examines factors associated with death and interhospital variation in treatment and outcomes in the US.
July 14, 2020 (JAMA)
Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers
Xiaowen Wang, MD; Enrico G. Ferro, MD; Guohai Zhou, PhD; et al
This study amongst healthcare workers in the Mass General Brigham (MGB) healthcare system in Massachusetts, USA, explores associations of hospital masking policies with the SARS-CoV-2 infection rates among HCW.
July 14, 2020 (The NEJM)
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, et al.
This article is a preliminary report on an ongoing open-label, phase 1 trial of mRNA Vaccine against SARS-CoV-2 conducted in Seattle and Atlanta, USA. The authors provide a current report on the immune response among the trial participants, and adverse effects from the vaccine.
July 10, 2020 (Journal of Immunology Research)
The Pathogenesis of Coronavirus Disease 2019 (COVID-19): Evaluation and Prevention
Ouassou, Hayat, Kharchoufa, Loubna, Bouhrim, Mohamed et al.
This study highlights the epidemiology, immunology, transmission, symptoms, and treatment of Covid-19, as well as explore potential strategies to control the spread of the disease.
July 10, 2020 (RadioGraphics)
RadioGraphics Update: Venous Thrombosis and Hypercoagulability in the Abdomen and Pelvis—Findings in COVID-19
Michael C. Olson, Meghan G. Lubner , Christine O. Menias et al.
This RadioGraphics update reviews current updates from prior studies done on radiological and imaging findings in COVID-19 patients that are associated with thromboembolic phenomena.
July 10, 2020 (The Lancet Haematology)
Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study
Danying Liao, Fen Zhou, Lili Luo et al.
Changes in haematological characteristics in patients with COVID-19 are emerging as important features of the disease. In this retrospective study, the authors explored the haematological characteristics and related risk factors in patients with COVID-19. They found that rapid blood tests, including platelet count, prothrombin time, D-dimer, and neutrophil to lymphocyte ratio can help clinicians to assess severity and prognosis of patients with COVID-19. The sepsis-induced coagulopathy scoring system can be used for early assessment and management of patients with critical disease.
July 10, 2020 (JAMA)
Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review
W, Joost Wiersinga, Andrew Rhodes, Allen C. Cheng et al.
This comprehensive and up-to-date review discusses current evidence regarding the pathophysiology, transmission, diagnosis, and management of COVID-19.
July 9, 2020 (The NEJM)
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in COVID-19
Ackermann M, Verleden SE, Kuehnel M, et al.
This study describes autopsy findings amongst patients who died from COVID-19, compared to similar patients who died from Influenza A(H1N1). The authors describe the inflammation and thrombotic findings in post-mortem COVID-19 lungs.
July 9, 2020 (Int. J of Dentistry)
COVID-19 Pandemic and Dental Practice
A.S Kochhar, R. Bhasin, G.K Kochhar, H. Dadlani
This paper provides a brief overview of the etiology, incubation, symptoms, and transmission paradigms of COVID-19 and how to minimize the spread in a dental healthcare setting. This review presents evidence-based patient management practice and protocols from the available literature to help formulate a contingency plan with recommendations, for the dental practices prior to patients’ visit, during in-office dental treatment, and post-treatment, during the pandemic and after.
July 8, 2020 (Infection, Disease & Health)
Understanding Covid-19 transmission: The effect of temperature and health behavior on transmission rates
This study examines factors that impact transmission rates in several countries in Europe, including containment measures and temperature.
July 8, 2020 (JAMA Netw. Open)
Association of a Public Health Campaign About Coronavirus Disease 2019 Promoted by News Media and a Social Influencer With Self-reported Personal Hygiene and Physical Distancing in the Netherlands
Hamza Yousuf, Jonathan Corbin, Govert Sweep et al.
This survey study examines a nationwide social media campaign about personal hygiene and physical distancing in the Netherlands and evaluates its effectiveness in improving behaviour and curbing the spread of the coronavirus disease 2019 (COVID-19) pandemic.
July 7, 2020 (Genes & Diseases)
Pandemic COVID-19: current status and challenges of antiviral therapies
Winglam Chan, Betsy He, Xiong Wang, Ming-Liang He
This article is a summary of the mechanisms of antiviral therapies that have been used for COVID-19 treatment and the clinical findings from different countries. These include Azithromycin, Hydroxycloroquine, Convalescent plasma (CP) therapy and Natural Killer (NK) Cell therapy.
July 2020 (Diagnostic and Interventional Imaging)
Chest CT in COVID-19 pneumonia: A review of current knowledge
C.Jalabera, T.Lapotreb, T.Morcet-Delattreb et al.
This review explores current updates in CT-scan findings in Covid-19, and their role in triaging patients in an emergency setting, as well as the utility of artificial intelligence in improving Covid-19 diagnosis and management.
July 6, 2020 (Clin Inf Dis)
It is Time to Address Airborne Transmission of COVID-19
Lidia Morawska, Donald K Milton
The authors review existing evidence of transmission of COVID-19 and are of the viewpoint that it is important to recognize the potential for airborne spread of COVID-19.
July 6, 2020 (JAMA)
Developing a SARS-CoV-2 Vaccine at Warp Speed
Kevin P. O’Callaghan, Allison M. Blatz, Paul A. Offit
In this Viewpoint, we describe the proposed mechanisms and current status of each of these leading candidates, all of which are aimed at inducing antibodies directed against the receptor-binding domain of the surface spike (S) protein of SARS-CoV-2.
July 3, 2020 (Cell)
Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear
Nathan D. Grubaugh, William P. Hanage, Angela L. Rasmussen
Korber et al. (2020) found that a SARS-CoV-2 variant in the spike protein, D614G, rapidly became dominant around the world. While clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, vaccine and therapeutic development are largely unknown. Here the authors try to answer questions on the potential impacts, if any, that D614G has on the COVID-19 pandemic.
July 3, 2020 (Science)
SARS-CoV-2 productively infects human gut enterocytes
Mart M. Lamers, Joep Beumer, Jelte van der Vaart et al.
SARS-CoV-2 causes an influenza-like disease with a respiratory transmission route;, however, patients often present with gastrointestinal symptoms such as diarrhoea. Lamers et al. used human intestinal organoids, a “mini-gut” cultured in a dish, to demonstrate that SARS-CoV-2 readily replicates in an abundant cell type in the gut lining—the enterocyte—resulting in the production of large amounts of infective virus particles in the intestine. This work demonstrates that intestinal organoids can serve as a model to understand SARS-CoV-2 biology and infectivity in the gut.
July 3, 2020 (The Lancet Haematology)
Effects of the COVID-19 pandemic on supply and use of blood for transfusion
Simon J Stanworth, Helen V New, Torunn O Apelseth et al.
The COVID-19 pandemic has major implications for blood transfusion. The authors systematically searched for relevant studies addressing the transfusion chain—from donor, through collection and processing, to patients—to provide a synthesis of the published literature and guidance during times of potential or actual shortage.
July 2, 2020 (The Lancet Child & Adolescent Health)
Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis
Naim Ouldali, Marie Pouletty, Patricia Mariani et al.
Kawasaki disease is an acute febrile systemic childhood vasculitis, which is suspected to be triggered by respiratory viral infections. The authors examined whether the ongoing COVID-19 epidemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with an increase in the incidence of Kawasaki disease.
July 2, 2020 (JAMA Neurology)
Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza
Alexander E. Merkler, Neal S. Parikh, Saad Mir et al.
This cohort study compares the rate of ischemic stroke among patients with COVID-19 vs patients with influenza in 2 hospitals in New York City, New York. They found that patients with COVID-19 appear to have a heightened risk of acute ischemic stroke compared with patients with influenza.
July 2, 2020 (Science)
Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques
Wei Deng, Linlin Bao, Jiangning Liu et al.
As the COVID-19 pandemic evolves, there are still many questions we need to answer. Currently, it remains unclear whether convalescing patients have a risk of reinfection. The authors generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. These results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques.
July 1, 2020 (JAMA Psychiatry)
Telehealth for Substance-Using Populations in the Age of Coronavirus Disease 2019: Recommendations to Enhance Adoption
Lewei (Allison) Lin, Anne C. Fernandez, Erin E. Bonar
This Viewpoint discusses the need for and implementation of telemedicine for patients with substance use disorder in the era of coronavirus disease 2019.
July 1, 2020 (JAMA Network Open)
Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the Coronavirus Disease 2019 Pandemic
Le Shi, Zheng-An Lu, Jian-Yu Que, et al.
This survey involving more than 50,000 participants estimated the prevalence of depression and anxiety, and also looked at the risk factors associated with mental health symptoms. The mental health burden associated with COVID-19 is considerable among the general population of China, suggesting that mental health interventions are in urgent demand during the COVID-19 pandemic, especially for some at-risk populations.
July 1, 2020 (Heliyon)
A one-step, one-tube real-time RT-PCR based assay with an automated analysis for detection of SARS-CoV2
Bhasker Dharavath, Neelima Yadav, Sanket Desai et al.
The authors present a rapid, easy to implement real-time PCR based assay with automated analysis using a novel COVID qPCR Analyzer tool with graphical user interface (GUI) to analyze the raw qRT-PCR data in an unbiased manner at a cost of under $3 per reaction and turnaround time of less than 2h, to enable in-house SARS-CoV-2 testing across laboratories.
August 31, 2020 (PNAS)
A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants
Bethany Dearlove, Eric Lewitus, Hongjun Bai et al.
The SARS-CoV-2 virus can mutate in a given individual, and these variants can be propagated across populations and time, raising questions about the possibility of a universally effective vaccine. To understand this mutation process, the authors analyze 18,514 SARS-CoV-2 sequences sampled since December 2019. They found that neutral evolution, rather than adaptive selection, can explain the rare mutations seen across SARS-CoV-2 genomes. Their results suggest that the limited diversity seen in SARS-CoV-2 should not preclude a single vaccine from providing global protection.
August 28, 2020 (NEJM)
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2
Anne L. Wyllie, John Fournier, Arnau Casanovas-Massana et al.
In this letter, the investigators report that saliva specimens and nasopharyngeal swab specimens had similar sensitivity in the detection of SARS-CoV-2 RNA in both symptomatic and asymptomatic persons.
August 28, 2020 (The Lancet Gastroenterology & Hepatology)
Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study
Gwilym J Webb, Thomas Marjot, Jonathan A Cook et al.
Despite concerns that patients with liver transplants might be at increased risk of adverse outcomes from COVID-19 because of coexisting comorbidities and use of immunosuppressants, the effect of SARS-CoV-2 infection on this patient group remains unclear. In this multicentre cohort study, the authors collected data to assess the clinical outcomes of COVID-19 in this cohort of patients.
August 26, 2020 (J of Int Medical Research)
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Olusola Bolaji et al.
The authors summarize all that we know to date on the SARS-CoV2 virus, epidemiology, pathophysiology, diagnosis and management. They present this knowledge in charts and graphics making it easy to understand.
August 25, 2020 (The Lancet Respiratory Medicine)
Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient
Christian Lang, Peter Jaksch, Mir Alireza Hoda et al.
The authors present a case report of a 44-year-old, female patient who had COVID-19-associated acute respiratory distress syndrome, requiring lung transplant. The case presented here extends the reports from China by showing that lung transplantation can be done in patients with positive RT-PCR results.
August 25, 2020 (EClinicalMedicine, The Lancet)
Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19
Sachin J. Shah, Peter N. Barish,Priya A. Prasad
The authors compared the clinical presentation, diagnostics, treatment, and outcomes between patients with COVID-19 and other acute respiratory illnesses. Whilst they found differences in clinical features of COVID-19 compared to other acute respiratory illnesses, there was significant overlap in presentation and comorbidities. Patients with COVID-19 were more likely to be admitted to the hospital, have longer hospitalizations and develop ARDS, and were unlikely to have co-existent viral infections.
August 24, 2020 (EBioMedicine, The Lancet)
Clinical, Immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR
Jing Lu, Jinju Peng, Qianling Xiong et al.
The authors collected data on patients who tested positive again for SARS-CoV-2 RNA following negative test results and discharge. They determined neutralization antibody titres and also looked for potential infectivity of clinical samples. They found that re-positive SARS-CoV-2 cases do not appear to be caused by active reinfection and were identified in ~14% of discharged cases. A robust NAb response and potential virus genome degradation were detected in almost all re-positive cases, suggesting a substantially lower transmission risk, especially through respiratory routes.
August 21, 2020 (JAMA)
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial
Christoph D. Spinner, Robert L. Gottlieb, Gerard J. Criner et al.
This open-label randomized trial compares the effect of remdesivir (5 or 10 days) vs standard care on clinical status 11 days after treatment initiation among patients with confirmed SARS-CoV-2 infection hospitalized with moderate pneumonia (room air oxygen saturation >94%).
August 20, 2020 (The Lancet Microbe)
Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study
Brian Hanley, Kikkeri N Naresh, Candice Roufosse et al.
In this case series of ten patients, the authors described the histopathological findings and viral tropism in patients who died of severe COVID-19.
August 20, 2020 (Process Biochemistry)
A systematic review on recent trends in transmission, diagnosis, prevention and imaging features of COVID-19
S. Manigandan, Ming-Tsang Wu, Vinoth Kumar Ponnusamy et al.
This study presents the perspective of different modes of transmission of coronavirus, especially during clinical practices and among the paediatrics. Further, the diagnostic methods and the advancement of the computerized tomography are discussed. This study also predicts the possible transmission of the virus through medical practices such as ophthalmology, dental, and endoscopy procedures. The authors also detail the current diagnostic methods for COVID-19.
August 18, 2020 (JAMA Int. Med.)
Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China
Fan Wu, Mei Liu, Aojie Wang et al.
This cohort study examines the levels of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 in patients who recovered from mild coronavirus disease 2019.
August 18, 2020 (NPJ Genomic Medicine)
Pharmacogenomics of COVID-19 therapies
Takahashi, T., Luzum, J.A., Nicol, M.R. et al.
In this review, the authors summarize the pharmacogenomic literature available for COVID-19 drug therapies including hydroxychloroquine, chloroquine, azithromycin, remdesivir, favipiravir, ribavirin, lopinavir/ritonavir, darunavir/cobicistat, interferon beta-1b, tocilizumab, ruxolitinib, baricitinib, and corticosteroids.
August 18, 2020 (The Lancet)
Effects of a major deletion in the SARS-CoV2 genome on the severity of the infection and the inflammatory response: an observational cohort study
Barnaby E Young, Siew-Wai Fong, Yi-Hao Chan et al.
SARS-CoV-2 variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. The authors investigate the effect of this deletion on the clinical features of infection. They found that the ∆382 variant of SARS-CoV-2 seems to be associated with a milder infection. The observed clinical effects of deletions in ORF8 could have implications for the development of treatments and vaccines.
August 17, 2020 (EBioMedicine, The Lancet)
SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of Placenta
Fabio Facchetti, Mattia Bugatti, Emma Drera et al.
The occurrence of trans-placental transmission of SARS-CoV-2 infection remains highly debated. Here, the authors provide evidence for maternal-fetal transmission of SARS-CoV-2, which they postulate is likely propagated by circulating virus-infected fetal mononuclear cells. The authors also describe the results of a comprehensive immunohistochemical and immunofluorescence analysis of the placental inflammatory infiltrate.
August 17, 2020 (EClinicalMedicine, The Lancet)
Risk factors for detection of SARS-CoV-2 in healthcare workers during April 2020 in a UK hospital testing programme
John S Leeds, Veena Raviprakash, Thomas Jacques et al.
The authors tested 991 healthcare workers in a single centre for SARS-Cov2 and examined risk factors associated with contracting the virus. They found that no specific variables were identified that altered the risk of SARS-CoV-2 RNA detection including age, sex, occupation and ethnicity.
August 17, 2020 (Ageing Research Reviews)
COVID-19: risk accumulation among biologically and socially vulnerable older populations
Amaia Calderón-Larrañaga, Serhiy Dekhtyar, Davide L.Vetrano et al.
In this paper, the authors propose a conceptual framework whereby different factors related to biological and social vulnerability may explain the specific COVID-19 burden among older people. The authors emphasize that interdisciplinary collaboration and biological, clinical and social data integration will be crucial to guide actions aimed at reducing older adults’ vulnerability to COVID-19.
August 15, 2020 (Academic Radiology)
Thorax Magnetic Resonance Imaging Findings in Patients with Coronavirus Disease (COVID-19)
Omer Faruk Ates, Onur Taydas, Hamad Dheir
The authors compared the findings found in thorax CT, which is increasingly used in the diagnosis of COVID-19, and the findings of MRI as an important diagnostic alternative.
August 8, 2020 (J of Oral Biology and Craniofacial Research)
Analysing COVID-19 pandemic through cases, deaths, and recoveries
Ilma Khan, Abid Haleem, Mohd Javaid
This paper aims to analyse the effect of the COVID-19 pandemic on different countries through COVID-19 cases to learn the right steps to contain the infection.
August 7, 2020 (Clin. Gastroenterology and Hepatology)
Systematic review on IBD patients with COVID-19: it is time to take stock
Ferdinando D’Amico, Silvio Danese, Laurent Peyrin-Biroulet
Clinical characteristics’ data of patients with inflammatory bowel diseases (IBD) with COVID-19 are scarce. The authors performed a systematic review to investigate symptoms and diagnostic-therapeutic management of IBD patients with COVID-19. They found that diarrhoea occurs more frequently in IBD patients with COVID-19 than in non-IBD population. However, further studies are needed to define the optimal diagnostic-therapeutic approach in IBD patients with COVID-19.
August 5, 2020 (Cell)
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik
In a dual-center, two-cohort study, the authors combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
August 4, 2020 (J of Pub. Health)
Post-COVID-19 precautions based on lessons learned from past pandemics: a review
Prakash Mallappa Munnoli, S. Nabapure, G. Yeshavanth
The authors perform a literature review on past pandemics and compared it to the current COVID-19 pandemic and share the lessons learned. A general awareness of COVID-19 infection is addressed, and it is compared with the Spanish flu pandemic. The authors conclude that based on the successes, failures and lessons learned in the past, governmental efforts must be undertaken to empower citizens by providing accurate information and implementing post-COVID-19 precautions that need to be taken now to stop the spread and recurrence of the virus locally, and to restore health and economic normalcy.
August 4, 2020 (J of Infection and Public Health)
COVID-19 and comorbidities: Deleterious impact on infected patients
Hasan Ejaz, Abdullah Alsrhani, Aizza Zafar et al
In this review, the authors focus on the impact of common morbidities in COVID-19 patients and recapitulated the management strategies with recent directions. They found limited resources describing the association of co-morbidities in COVID-19.
Aug 4, 2020 (JAMA Network Open)
Prevalence of Health Care Worker Burnour during the Coronavirus Disease 2019 (COVID-19) Pandemic in Japan
Takahiro Matsuo, Daiki Kobayashi, Fumika Taki et al.
This cross-sectional study evaluates the prevalence of and factors associated with burnout among frontline health care workers during the coronavirus disease 2019 (COVID-19) pandemic in Japan.
Aug 4, 2020 (JAMA)
Airborne Transmission of SARS-CoV2: Theoretical considetations and Available Evidence
Michael Klompas, Meghan A. Baker, Chanu Rhee et al.
This Viewpoint discusses physical and epidemiological evidence supporting droplet vs aerosol transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and concludes on balance that aerosol transmission seems unlikely to be the dominant mode of coronavirus disease 2019 (COVID-19) spread.
June 27, 2020 (Current Problems in Diagnostic Radiology)
Current landscape of Imaging and the potential role for Artificial intelligence in the management of COVID-19
Faiq Shaikh, Michael Anderson, M. Rizwan Sohail et al.
Medical imaging plays a critical role in the early detection, clinical monitoring and outcomes assessment of COVID-19. Chest x-ray radiography (CXR) and computed tomography (CT) are the standard imaging modalities used for the structural assessment of the disease status. Artificial intelligence (AI) can enhance the predictive power and utilization of these imaging approaches and new approaches focusing on detection, stratification and prognostication are showing encouraging results. The authors review the current landscape of these imaging modalities and AI approaches as applied in COVID-19 management.
June 26, 2020 (European Radiology)
Evaluation of novel coronavirus disease (COVID-19) using quantitative lung CT and clinical data: prediction of short-term outcome.
Matos, J., Paparo, F., Mussetto, I. et al.
Volume of disease (VoD) on computed tomography (CT) scan and clinical information predict early outcome in COVID-19 patients. The authors measured VoD on CT scan of 106 COVID-19 positive patients using a simple CT post-processing tool. They found that CT and clinical data together enable accurate prediction of short-term clinical outcome.
June 26, 2020 (European Radiology)
Quantitative chest CT analysis in COVID-19 to predict the need for oxygenation support and intubation
Ezio Lanza, Riccardo Muglia, Isabella Bolengo et al.
The authors performed a single-centre retrospective study on COVID-19 patients hospitalised from January 25, 2020, to April 28, 2020, who received CT at admission prompted by respiratory symptoms such as dyspnea or desaturation. The authors tested quantitative CT analysis (QCT) as an outcome predictor for COVID-19. They found that may serve as a tool for the triaging process of COVID-19.
June 25, 2020 (Vaccine)
Contingent assessment of the COVID-19 vaccine
Leidy Y. García, Arcadio A. Cerda
The authors estimated an individual’s willingness to pay (WTP) for a hypothetical COVID-19 vaccine and, at the same time, find the main factors that determine this valuation.
June 25, 2020 (Psychological Trauma: Theory, Research, Practice, and Policy)
The Coronavirus Pandemic in Malaysia: A Commentary
The author expresses her views on how the COVID-19 pandemic is affecting the Malaysian population from a mental health perspective. She also explains how the Malaysian health care system is organised and discusses the response of the people to the pandemic.
June 24, 2020 (JAMA Netw. Open)
Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial
Spyridon G. Deftereos, Georgios Giannopoulos, Dimitrios A. Vrachatis et al. https://doi.org/10.1001/jamanetworkopen.2020.13136
This randomized clinical trial evaluates the effect of treatment with colchicine on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019 (COVID-19). Participants who received colchicine had statistically significantly improved time to clinical deterioration. However, this must be interpreted with caution.
June 19, 2020 (Science)
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Wenhao Dai, Bing Zhang, Xia-Ming Jiang et al.
With no vaccine or proven effective drug against the SARS-CoV2 virus, scientists are racing to find clinical antiviral treatments. A promising drug target is the viral main protease Mpro, which plays a key role in viral replication and transcription. Dai et al.designed two inhibitors, 11a and 11b, based on analyzing the structure of the Mpro active site. Both strongly inhibited the activity of Mpro and showed good antiviral activity in cell culture. Compound 11a had better pharmacokinetic properties and low toxicity when tested in mice and dogs, suggesting that this compound is a promising drug candidate.
June 19, 2020 (Science)
COVID-19 and cancer
Norman E. Sharpless
The author discusses the impact of the COVID-19 pandemic on cancer. From causing delayed diagnosis and suboptimal care for people with cancer, to unprecedented disruption throughout the cancer research community, there is valid concern that this will be a step backwards for the cancer community.
June 19, 2020 (JAMA)
Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality
Emil L. Fosbøl, Jawad H. Butt, Lauge Østergaard, et al
This cohort study uses Danish registry data to estimate the association between a prescription for angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) in the 6 months prior to a coronavirus disease 2019 (COVID-19) diagnosis and mortality among all patients and those with hypertension.
June 18, 2020 (JAMA Otolaryngol Head Neck Surg.)
Prevalence of Taste and Smell Dysfunction in Coronavirus Disease 2019
Giuseppe Mercante, Fabio Ferreli, Armando De Virgilio et al.
This survey study of patients with coronavirus disease 2019 investigates the presence of sinonasal manifestations at the onset of the disease to achieve an earlier diagnosis.
June 18, 2020 (The Lancet Diabetes & Endocrinology)
Association between high serum total cortisol concentrations and mortality from COVID-19
Tricia Tan, Bernard Khoo, Edouard G Mills et al.
The increase in cortisol is an essential part of the body's stress response, triggering adaptive changes in metabolism, cardiovascular function, and immune regulation. The authors performed a cohort study describing the acute cortisol concentrations observed in patients with COVID-19. They found that cortisol seemed to be a better independent predictor than were other laboratory markers associated with COVID-19, such as CRP, D-dimer, and neutrophil to leukocyte ratio.
June 18, 2020 (Clinical and Translational Radiation Oncology)
Conducting research in Radiation Oncology remotely during the COVID-19 pandemic: Coping with isolation
Jennifer Dhont, Marialaura Di Tella, Ludwig Dubois et al.
The authors carried out a survey amongst researchers in the field of radiation oncology to gain insights on the impact of social isolation and working from home and to guide future work. They found that perceived productivity was lower, with associated feelings of guilt. Additionally, Anxiety and depressive symptoms were higher than normative values in Europe. They also found that mental health symptoms were lower in participants with institutional health support.
June 17, 2020 (The Lancet Infectious Disease)
Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study
Qin-Long Jing, Ming-Jin Liu, Zhou-Bin Zhang et al.
The authors estimated the secondary attack rate of SARS-CoV-2 among household and non-household close contacts in Guangzhou, China, using a statistical transmission model. They found that SARS-CoV2 is more transmissible in households than SARS-CoV and Middle East respiratory syndrome coronavirus. Older individuals (aged ≥60 years) are the most susceptible to household transmission of SARS-CoV-2.
June 17, 2020 (Jama Int. Med.)
Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure
Alison E. Thompson, Benjamin L. Ranard, Ying Wei, Sanja Jelic.
This cohort study investigates whether the prone position is associated with improved oxygenation and decreased risk for intubation in spontaneously breathing patients with severe COVID-19 hypoxemic respiratory failure.
June 16, 2020 (The Lancet Rheumatology)
GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study
Giacomo De Luca, Giulio Cavalli, Corrado Campochiaro et al.
This single-centre prospective cohort study included patients aged 18 years or older with severe COVID-19 pneumonia, hypoxia, and systemic hyperinflammation. Patients received a single intravenous dose (6 mg/kg) of mavrilimumab added to standard care given by the hospital at the time. The control group consisted of contemporaneous patients with similar baseline characteristics who received standard care at the same hospital. Mavrilimumab treatment was associated with improved clinical outcomes compared with standard care in non-mechanically ventilated patients with severe COVID-19 pneumonia and systemic hyperinflammation.
June 16, 2020 (Immunity)
Immunology of COVID-19: Current State of the Science
Nicolas Vabret, Graham J. Britton, Conor Gruber et al.
In this review, the authors summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. They also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
June 15, 2020 (Science)
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
Philip J. M. Brouwer, Tom G. Caniels, Karlijn van der Straten et al.
The authors describe their work in isolating monoclonal antibodies from three convalescent COVID-19 patients using a SARS-CoV-2 stabilized prefusion spike protein. They found that a subset of the antibodies were able to potently inhibit authentic SARS-CoV-2 infection as low as 0.007 μg/mL. In addition to providing guidance for vaccine design, the antibodies described here are promising candidates for COVID-19 treatment and prevention.
June 15, 2020 (The Lancet)
Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study
Andrew Clark, Mark Jit, Charlotte Warren-Gash et al.
The authors estimated the number of individuals at increased risk of severe COVID-19 and to see how this varies between countries to inform the design of possible strategies to shield or vaccinate those at highest risk. They found that about one in five individuals worldwide could be at increased risk of severe COVID-19, should they become infected, due to underlying health conditions, but this risk varies considerably by age.
June 15, 2020 (Chest)
Tocilizumab treatment for Cytokine Release Syndrome in hospitalized COVID-19 patients: survival and clinical outcomes
Christina C.Price, Frederick L.Altice, YuShyr
In this observational study, the authors followed through COVID-19 patients who were treated with tocilizumab using an algorithm that targeted Cytokine Release Syndrome (CRS). The authors found that in tocilizumab-treated patients, oxygenation and inflammatory biomarkers improved with higher than expected survival.
June 15, 2020 (JAMA)
Monoclonal Antibodies for Prevention and Treatment of COVID-19
Mary Marovich, John R. Mascola, Myron S. Cohen
This Viewpoint discusses the potential role of neutralizing monoclonal antibodies (MAbs) as a treatment for coronavirus disease 2019 (COVID-19) and as a means of prevention in high-risk populations, and it also raises possible limitations of the approach that need to be disproven or addressed for the strategy to be effective.
June 12, 2020 (JAMA Patient Page)
Convalescent Plasma and COVID-19
Anurag N. Malani, John P. Sherbeck, Preeti N. Malani
This JAMA Patient Page describes the possible benefits of convalescent plasma transfusion in the treatment of COVID-19 as well as plasma donation eligibility criteria.
June 12, 2020 (JAMA Surgery)
Factors Associated With Surgical Mortality and Complications Among Patients With and Without Coronavirus Disease 2019 (COVID-19) in Italy
Francesco Doglietto, Marika Vezzoli, Federico Gheza et al.
This cohort study compares early surgical outcomes of patients in Italy with and without COVID-19 in different subspecialties. In this study of 41 surgical patients with COVID-19 and 82 tightly matched control patients without COVID-19, significant differences were documented regarding rates of early mortality and complications, pneumonia and thrombotic complications were significantly associated with COVID-19. Based on these results, the authors suggest that surgery should be postponed in patients with COVID-19, wherever possible.
June 12, 2020 (Science)
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
Yan Wu, Feiran Wang, Chenguang Shen et al.
One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat viral diseases. Wu et al. isolated four neutralizing antibodies from a convalescent coronavirus disease 2019 (COVID-19) patient and describe them in detail in this article.
June 12, 2020 (Science)
The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries
Patrick G. T. Walker, Charles Whittaker, Oliver J Watson et al.
The ongoing COVID-19 pandemic has affected everyone. The authors combine data on demography, contact patterns, disease severity, and health care capacity and quality to understand its impact and inform strategies for its control.
June 11, 2020 (JAMA Network Open)
Temperature, Humidity, and Latitude Analysis to Estimate Potential Spread and Seasonality of Coronavirus Disease 2019 (COVID-19)
Mohammad M. Sajadi, Parham Habibzadeh, Augustin Vintzileos et al.
This cohort study examines the association between climate and the spread of coronavirus disease 2019 (COVID-19) infection.
June 11, 2020 (The Lancet)
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study
Silvia Stringhini, Ania Wisniak, Giovanni Piumatti et al.
The authors perform a population based study to measure the prevalence of anti-SARS-CoV-2-IgG antibodies using a commercially available ELISA. They performed weekly measurements and report the results of 5 weeks of measurement between April 6, 2020 - May 9, 2020. Assuming that the presence of IgG antibodies is associated with immunity, the results suggest tha most of the population of Geneva remained uninfected during this wave of the pandemic. The authors estimate that for every reported confirmed case, there were 11·6 infections in the community. They hope to continue this study to complete 12 weeks.
June 11, 2020 (JAMA Network Open)
Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China
Dong Chen, Xiaokun Li, Qifa Song, et al.
This cohort study investigates the prevalence, causes, and clinical implications of hypokalemia, including its possible association with treatment outcomes, among patients with coronavirus disease 2019 (COVID-19) in Wenzhou, China.
June 10, 2020 (Vaccine)
Vaccination against coronaviruses in domestic animals
Ian R. Tizard
In search for a vaccine against SARS-CoV2 in humans, the authors discuss the development and use of coronavirus vaccines in domestic animal species. Although these animal vaccines will in no way protect humans against COVID-19 but knowledge of the difficulties encountered in vaccinating animals may help avoid or minimize similar problems arising in humans.
June 10, 2020 (AJR)
Diagnostic Ultrasound Services During the Coronavirus Disease (COVID-19) Pandemic
Apoorva Gogna, Praveen Yogendra, Sally Hsueh Er Lee et al.
The authors share their experiences and protocols of performing diagnostic ultrasounds during the COVID-19 pandemic to prevent risk of transmission of COVID-19 from patients to healthcare workers.
June 9, 2020 (JAMA)
Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit
Chiara Sartini, Moreno Tresoldi, Paolo Scarpellini et al.
This study measured respiratory parameters of 15 non-ICU patients before, during, and after receiving noninvasive ventilation in the prone position.
June 6, 2020 (Mayo Clinic Proceedings)
Clinical Trial Endpoints in Severe COVID-19
Desai A, Kulkarni A, Rajkumar SV, Gyawali
This commentary highlights the endpoints focused by ongoing clinical trials on COVID-19 and the need for focus on mortality as an endpoint in trials for Severe COVID-19.
June 6, 2020 (Mayo Clinic Proceedings)
Innovation Lessons From the COVID-19 Pandemic
Gianrico Farrugia, Roshelle W. Plutowski
The authors highlight how health care organizations, industry partners, and government agencies worldwide have quickly come together to address the challenges of the COVID19 pandemic such as scaling high-quality laboratory tests, conducting treatment research, and enabling virtual health care in a time of social distancing. These accomplishments demonstrate the opportunity for future cross-sector partnerships in science and technology to fight the disease, while simultaneously creating the new digital health care solutions that our world greatly needs.
June 6, 2020 (European J of Medicinal Chemistry)
A Promising Antiviral Candidate Drug for the COVID-19 Pandemic: A Mini-Review of Remdesivir
Chengyuan Liang, Lei Tian, Yuzhi Liu et al.
This article provides a comprehensive overview of remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor. The remdesivir synthetic routes were comprehensively collected and are presented as a compilation of roadmaps. The authors also summarise clinical trial information of remdesivir for the treatment of COVID-19.
June 5, 2020 (Infection, Disease & Health)
Concerns for low-resource countries, with under-prepared intensive care units, facing the COVID-19 pandemic
Muhammad Elhadi, Ahmed Msherghi, Mohammed Alkeelani et al.
The authors report the healthcare system preparedness for COVID-19 in low resource settings and provides insight to the shortage of personal protective equipment in Africa. They also highlight the health care situation during the civil war and COVID 19 outbreak in Libya, as well as the infrastructure status of intensive care units in Libya.
June 4, 2020 (JAMA)
Correlation Between N95 Extended Use and Reuse and Fit Failure in an Emergency Department
Nida F. Degesys, Ralph C. Wang, Elizabeth Kwan et al.
This cross-sectional study examines prevalence of fit test failure of 2 types of N95 mask (dome-shaped and duckbill) during extended use or reuse among health care workers over 2 days in April 2020 in the UCSF emergency department. They found that duckbill N95s had a high failure rate. Failure of dome-shaped masks was associated with increased use.
June 4, 2020 (JAMA)
Challenge Trials—Could Deliberate Coronavirus Exposure Hasten Vaccine Development?
This Medical News feature discusses the debate over human challenge trials to test the safety and efficacy of coronavirus disease 2019 (COVID-19) vaccine candidates.
June 3, 2020 (JAMA)
Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial
Ling Li, Wei Zhang, Yu Hu et al.
The authors performed a randomized clinical trial to ascertain if there was any benefit of using convalescent plasma therapy in treating severe COVID-19. They found that among 103 patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment did not significantly improve the time to clinical improvement within 28 days. However, interpretation is limited by early termination of the trial, which may have been underpowered to detect a clinically important difference.
June 3, 2020 (NEJM)
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
David R. Boulware, Matthew F. Pullen, Ananta S. Bangdiwala et al.
In this double-blind, randomised trial, 821 asymptomatic persons with a high-risk or moderate-risk exposure to SARS-CoV-2 were assigned to receive hydroxychloroquine or placebo within 4 days after the exposure. No benefit in preventing illness compatible with COVID-19 was found.
June 3, 2020 (NEJM)
Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing
Yuan-Po Tu, Rachel Jennings, Gerard A. Cangelosi, et al.
Tongue, nasal and mid-turbinate swabs to detect SARS-CoV-2 were collected by 530 outpatients before a health care worker collected nasopharyngeal swabs from these patienta. Both the mid-turbinate and nasal samples collected by the patients themselves may be clinically acceptable, with estimated sensitivities above 90%.
June 3, 2020 (The Lancet)
The impact of ethnicity on clinical outcomes in COVID-19: A systematic review
Daniel Pan, Shirley Sze, Jatinder S. Minhas, et al.
The authors performed a systematic review to assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes. Data on ethnicity in patients with COVID-19 in the published medical literature remains limited. However, emerging data from the grey literature and preprint articles suggest Black, Asian and Minority Ethnic (BAME) individuals are at an increased risk of acquiring SARS-CoV-2 infection compared to White individuals and also worse clinical outcomes from COVID-19.
June 3, 2020 (JAMA)
Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial
Ling Li, Wei Zhang, Yu Hu, et al.
This randomized trial compares the effects of convalescent plasma therapy with standard care vs standard care alone on time to clinical improvement among patients with severe or life-threatening COVID-19 disease in China. The authors found that among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to clinical improvement within 28 days.
June 2, 2020 (The Lancet Public Health)
Effects of non-pharmaceutical interventions on COVID-19 cases, deaths, and demand for hospital services in the UK: a modelling study
Nicholas G Davies, Adam J Kucharski, Rosalind M Eggo, et al
Non-pharmaceutical interventions have been implemented to reduce transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the UK. This study assesses the potential impact of different control measures for mitigating the burden of COVID-19 in the UK.
June 2, 2020 (Int J of Infectious Diseases)
COVID-19 Outbreak in Malaysia: Actions Taken by the Malaysian Government
Ain Umaira Md Shah, Syafiqah Nur Azrie Safri, Rathedevi Thevadas et al.
This article shares the Malaysian experience of managing the COVID-19 pandemic. The authors share the actions taken by the Malaysian government such as the movement control order, amongst other steps to mitigate the spread of the disease.
June 1, 2020 (The Lancet)
Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis
Derek K Chu, Elie A Akl, Stephanie Duda, et al.
The authors performed systematic review and meta-analysis to investigate the optimum distance for avoiding person-to-person virus transmission and to assess the use of face masks and eye protection to prevent transmission of viruses. They reviewed 172 observational studies across 16 countries and six continents and their findings support physical distancing of 1 m or more and provide quantitative estimates for models and contact tracing to inform policy.
June 2020 (American Journal of Infection Control)
A qualitative study on the psychological experience of caregivers of COVID-19 patients
Niuniu Sun, Luoqun Wei, Suling Shi et al.
In this qualitative study, the authors explore the psychology of nurses caring for COVID-19 patients. They enrolled 20 nurses who provided care for COVID-19 patients using a phenomenological approach. They found that nurses showed interweaving positive and negative emotions during outbreak of COVID-19, with negative emotions being dominant in the early stages of the COVID-19 outbreak. They emphasised that coping styles and psychological growth are important for maintaining mental health.
June 2020 (Journal of Nursing Research)
Nursing Perspectives on the Impacts of COVID-19
CHEN, Shu-Ching, LAI, Yeur-Hur, TSAY, Shiow-Luan
Nurses are the frontline healthcare professionals who work across acute care hospitals, long-term care agencies, nursing homes, schools, community, and government healthcare agencies. The multiple roles and functions played by nurses are particularly important during this COVID-19 pandemic and the authors highlight the nurses contribution across 5 main domains. They also discuss the key challenges faced by nursing professionals during this pandemic.
May 30, 2020 (J of American Academy of Dermatology)
Pernio-like skin lesions associated with COVID-19: A case series of 318 patients from 8 countries
Esther E. Freeman, Devon E. McMahon, Jules B. Lipoff et al.
An international dermatology registry was circulated to health care providers worldwide through the American Academy of Dermatology, International League of Dermatologic Societies, and other organizations. The authors documented 505 patients with dermatologic manifestations associated with COVID-19, including 318 (63%) with pernio-like lesions. Patients with pernio-like lesions were generally young and healthy, with relatively mild COVID-19. The authors conclude that pernio-like skin changes of the feet and hands, without another explanation, may suggest COVID-19 infection and should prompt confirmatory testing.
May 30, 2020 (European Radiology)
CT in coronavirus disease 2019 (COVID-19): a systematic review of chest CT findings in 4410 adult patients
Ojha, V., Mani, A., Pandey, N.N. et al.
The authors performed a systematic review to evaluate the key imaging manifestations of COVID-19 on chest CT in adult patients. They included 45 studies comprising 4410 patients. This review describes the imaging features for diagnosis, stratification, and follow-up of COVID-19 patients. The most common CT manifestations are bilateral, peripheral/subpleural, posterior GGOs with or without consolidations with a lower lobe predominance.
May 29, 2020 (JAMA Neurology)
Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review
Adeel S. Zubair, Lindsay S. McAlpine, Tova Gardin et al.
This narrative review identifies potential tissue targets and routes of entry of severe acute respiratory syndrome coronavirus 2 into the central nervous system and reported neurological complications of coronavirus disease 2019.
May 29, 2020 (Science)
The Search for a COVID-19 Animal Model
Seema S. Lakdawala, Vineet D. Menachery
Translating data from a single animal model to the varied disease outcomes in humans is not only challenging, but potentially misleading. Studies examining the efficacy of vaccines and antiviral drugs traditionally use models of severe disease, which may not mimic the common pathology in the majority of COVID-19 patients and could limit understanding of other important questions, including infection dynamics and transmission. Here, the authors compare currently available animal models for SARS-CoV-2 infection and COVID-19 in search for the best animal model to study COVID-19.
May 28, 2020 (Experimental Biology and Medicine)
The amount of cytokine-release defines different shades of Sars-Cov2 infection
S Bindolli, M Felicetti, P Sfriso et al.
This minireview contributes to providing a point of view regarding the immunological mechanisms beyond COVID-19 infection. Base on current evidence, the authors suggest to classify patients into three main clinical phenotypes according to the amount and pattern of cytokines released during the infection. By evaluating the degree of immunological activation provoked by SARS-CoV2, this article contributes in understanding better how to choose the correct clinical approach with immuno-modulatory therapies which, in turn, may help in curbing the hyper-inflammatory condition of patients affected.
May 28, 2020 (The Lancet Oncology)
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study
Nicole M Kuderer, Toni K Choueiri, Dimpy P Shah et al.
The authors characterise the outcomes of a cohort of 928 patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness.
May 28, 2020 (European Radiology)
Any unique image biomarkers associated with COVID-19?
Pu, J., Leader, J., Bandos, A. et al.
The authors compared CT scans of COVID-19 and Non-COVID19 community acquired pneumonia patients to define the uniqueness of chest CT infiltrative features associated with COVID-19 image characteristics as potential diagnostic biomarkers. They found that unique image features or patterns may not exist for reliably distinguishing all COVID-19 from CAP; however, there may be imaging markers that can identify a sizeable subset of non-COVID-19 cases.
May 27, 2020 (Malaysian Orthopaedic Journal)
N95 Filtering Facepiece Respirators during the COVID-19 Pandemic: Basics, Types, and Shortage Solutions
Srinivasan S, Peh WCG
There is much global concern about protective measures for health care professionals, particularly those performing surgery or other procedures with close patient contact during this COVID-19 pandemic. Here the authors discuss N95 respirators and the additional role of powered air-purifying respirators (PAPR) is also discussed.
May 27, 2020 (Cell)
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
Yixuan J. Hou, Kenichi Okuda, Caitlin E. Edwards et al.
The authors utilized a reverse genetics system to generate a GFP reporter virus to explore SARS-CoV-2 pathogenesis. The found that the reagents used provide a foundation for investigations into virus-host interactions in protective immunity, host susceptibility, and virus pathogenesis.
May 27, 2020 (Science)
Reducing transmission of SARS-CoV-2
Kimberly A. Prather, Chia C Wang, Robert T. Schooley
The authors discuss the role of aerosol spread of the SARS-CoV2 virus and emphasise the need for masks to combat asymptomatic spread in aerosols and droplets.
May 27, 2020 (JAMA Internal Medicine)
Opening Hospitals to More Patients During the COVID-19 Pandemic—Making It Safe and Making It Feel Safe
David A. Asch
This essay details the importance in the COVID-19 era of making the changes needed to ensure that hospitals are safe for all patients who want to use them and, as importantly, to ensure that the patients feel that they are safe.
May 27, 2020 (JAMA)
Comparison of Clinical Characteristics of Patients with Asymptomatic vs Symptomatic Coronavirus Disease 2019 in Wuhan, China
Rongrong Yang, Xien Gui, Yong Xiong
This case series examines clinical characteristics of patients with asymptomatic vs symptomatic coronavirus disease 2019 in Wuhan, China.
May 27, 2020 (JAMA Psychiatry)
Psychiatry in Times of the Coronavirus Disease 2019 (COVID-19) Pandemic: An Imperative for Psychiatrists to Act Now
Luykx JJ, Vinkers CH, Tijdink JK.
This Viewpoint discusses how psychiatrists can contribute to diminish the effects of the coronavirus disease 2019 (COVID-19) pandemic.
May 27, 2020 (NEJM)
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19
Jason D. Goldman, David C.B. Lye,David S. Hui, Kristen M. Marks et al.
The authors conducted a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed severe SARS-CoV-2 infection. 397 patients were randomly assigned in a 1:1 ratio to receive intravenous remdesivir for either 5 days or 10 days. All patients received 200 mg of remdesivir on day 1 and 100 mg once daily on subsequent days. In patients with severe Covid-19 not requiring mechanical ventilation, the trial did not show a significant difference between a 5-day course and a 10-day course of remdesivir. With no placebo control, however, the magnitude of benefit cannot be determined.
May 26, 2020 (Clinica Chimica Acta)
COVID-19: Transmission, prevention, and potential therapeutic opportunities
Melika Lotfi, Michael R. Hamblin, Nima Rezaei
The authors review current evidence and present current therapeutic options, preventive methods and transmission routes of COVID-19
May 26, 2020 (United European Gastroenterology Journal)
Liver Injury in COVID-19: The Current Evidence
Saleh A Alqahtani, Jorn M Schattenberg
This review summarizes current evidence related to hepatobiliary complications in COVID-19, provides an overview of the available case series and critically elucidates the proposed mechanisms and provides recommendations for clinicians.
May 26, 2020 (Otolaryngology– Head and Neck Surgery)
Inappropriate Nasopharyngeal Sampling for SARS-CoV-2 Detection Is a Relevant Cause of False-Negative Reports
Antonio Piras, Davide Rizzo, Sergio Uzzau et al.
The authors describe 4 symptomatic patients with negative RT-PCR results at the first nasopharyngeal swab, which became positive when collected a few hours later by an otolaryngologist, suggesting that inadequate nasopharyngeal sampling performed by untrained operators in the presence of nasal obstruction can be a relevant case of false-negative findings at RT-PCR, with a clear negative impact on the efforts to contain the current outbreak.
May 22, 2020 (JAMA)
Translating Science on COVID-19 to Improve Clinical Care and Support the Public Health Response
Carlos del Rio, Preeti Malani
The authors summarize the flood of communication about the most important aspects of the COVID-19-pandemic published in the last five months.
May 22, 2020 (The Lancet)
Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial
Feng-Cai Zhu, Yu-Hua Li, Xu-Hua Guan, et al
The authors assessed the safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 (Ad5) vectored COVID-19 vaccine expressing the spike glycoprotein of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain. Their findings show that the Ad5 vectored COVID-19 vaccine is tolerable and immunogenic at 28 days post-vaccination, suggesting that this vaccine warrants further investigation.
May 22, 2020 (JAMA)
Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China
Jinru Wu, Xinyi Liu, Jianjun Liu, Han Liao, Sixuan Long, Ning Zhou, Pa Wu
This cross-sectional study used reverse transcriptase–polymerase chain reaction tests to assess potential viral shedding among patients who previously had been diagnosed with and had clinically recovered from coronavirus disease 2019.
May 22, 2020 (JAMA)
Nursing Home Care in Crisis in the Wake of COVID-19
David C. Grabowski, Vincent Mor
This Viewpoint discusses the long-standing deficiencies in nursing home financing and organization made worse by the spread of coronavirus disease 2019 (COVID-19), and proposes ways to improve testing and personal protective equipment availability, and payment reforms to incentivize quality care for residents and decrease emergency department and hospital use.
May 22, 2020 (Science)
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period
Stephen M. Kissler, Christine Tedijanto, Edward Goldstein, Yonatan H. Grad, Marc Lipsitch
Kissler et al. used existing data to build a deterministic model of multiyear interactions between existing coronaviruses, with a focus on the United States, and used this to project the potential epidemic dynamics and pressures on critical care capacity over the next 5 years. The long-term dynamics of SARS-CoV-2 strongly depends on immune responses and immune cross-reactions between the coronaviruses, as well as the timing of introduction of the new virus into a population. One scenario is that a resurgence in SARS-CoV-2 could occur as far into the future as 2025.
May 22, 2020 (The Lancet)
Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis
Prof Mandeep R Mehra, Sapan S Desai, Prof Frank Ruschitzka, Amit N Patel
The authors performed a multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19. The registry comprised data from 671 hospitals in six continents. They were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.
May 22, 2020 (Clinical Infectious Diseases)
Predicting infectious SARS-CoV-2 from diagnostic samples
Jared Bullard, Kerry Dust, Duane Funk, James E Strong, David Alexander et al.
An RT-PCR test for SARS-CoV2 detects RNA but not infectious virus, thus its ability to determine duration of infectivity of patients is limited. Infectivity is a critical determinant in informing public health guidelines/interventions. Here, the authors perform a retrospective cross-sectional study and took SARS-CoV-2 RT-PCR confirmed positive samples and determined their ability to infect Vero cell lines. They found that cell infectivity was only observed for samples with PCR Cycle time < 24 and from patients with < 8 days from symptom onset.
May 21, 2020 (Infection)
A simple algorithm helps early identification of SARS-CoV-2 infection patients with severe progression tendency
Qiang Li, Jianliang Zhang, Yun Ling et al.
The authors performed univariable and multivariable analysis to identify the independent predictors of COVID-19 progression. The prediction model was established in a retrospective training set of 322 COVID-19 patients and was re- evaluated in a prospective validation set of 317 COVID-19 patients. They found that The age-LDH-CD4 model is a simple algorithm for early identifying patients with severe progression tendency following SARS-CoV-2 infection, and warrants further validation.
May 21, 2020 (JAMA)
Postmortem Examination of Patients With COVID-19
Tina Schaller, Klaus Hirschbühl, Katrin Burkhardt, Georg Braun, Martin Trepel, Bruno Märkl, Rainer Claus
This case series describes autopsy findings in 10 patients with proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who died at a university medical center in Germany. They found that acute and organizing diffuse alveolar damage and SARS-CoV-2 persistence in the respiratory tract were the predominant histopathologic findings and constituted the leading cause of death in patients with and without invasive ventilation.
May 21, 2020 (Int J of Social Psychiatry)
Impact of Social Distancing on Mental Health during the COVID-19 Pandemic: An Urgent Discussion
Matias Carvalho Aguiar Melo, Douglas de Sousa Soares
In this letter to the editor, the authors discuss the psychological impact of social distancing and emphasise the urgent need to conduct more researches to clarify the effect of social distancing in short- and long-term mental health.
May 20, 2020 (Nature Communications)
Immunogenicity of a DNA vaccine candidate for COVID-19
Smith, T.R.F., Patel, A., Ramos, S. et al.
In this paper, the authors discuss their findings after generating a synthetic DNA-based vaccine candidate targeting SARS-CoV-2 S protein. The engineered construct, INO-4800, results in robust expression of the S protein in vitro. Following immunization of mice and guinea pigs with INO-4800, they measured antigen-specific T cell responses, functional antibodies which neutralize the SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and biodistribution of SARS-CoV-2 targeting antibodies to the lungs. This preliminary dataset identifies INO-4800 as a potential COVID-19 vaccine candidate, supporting further translational study.
May 20, 2020 (Science)
DNA vaccine protection against SARS-CoV-2 in rhesus macaques
Jingyou Yu, Lisa H. Tostanoski, Lauren Peter et al.
The authors developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 Spike (S) protein and evaluated them in 35 rhesus macaques. They found that vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers comparable to those found in convalescent humans and macaques infected with SARS-CoV-2. Following vaccination, all animals were challenged with SARS-CoV-2, and the authors found reductions in median viral loads in bronchoalveolar lavage and nasal mucosa samples from these macaques, as compared with sham controls. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate vaccine protection against SARS-CoV-2 in nonhuman primates.
May 20, 2020 (NEJM)
Pandemic as Teacher — Forcing Clinicians to Inhabit the Experience of Serious Illness
Jane deLima Thomas
The author shares her experience and challenges as a palliative care physician in preparing for the COVID-19 pandemic.
May 20, 2020 (JAMA)
Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults
Supinda Bunyavanich, Anh Do, Alfin Vicencio
The authors conducted a retrospective examination of nasal epithelium collected from individuals aged 4 to 60 years encountered within the Mount Sinai Health System, New York, during 2015-2018. They investigated ACE2 gene expression in the nasal epithelium of these children and adult samples and found that there is age-dependent expression of ACE2 in nasal epithelium, possibly explaining why COVID-19 is less prevalent in children.
May 20, 2020 (JAMA)
Olfactory Dysfunction in COVID-19: Diagnosis and management
Katherine Lisa Whitcroft, Thomas Hummel
This JAMA Insights Clinical Update discusses the presumed mechanism of COVID-19–related olfactory dysfunction and proposes assessment and management strategies, including olfactory training and adjuvant medication treatments.
May 20, 2020 (JAMA)
Assessment of Proficiency of N95 Mask Donning Among the General Public in Singapore
Wesley Yeung, Kennedy Ng, J. M. Nigel Fong, Judy Sng, Bee Choo Tai, Sin Eng Chia
The authors conducted a cross-sectional study to evaluate the proficiency of members of the Singapore public in wearing N95 masks. Participants were provided with the same model of masks and an instruction sheet. Interviewers administered a visual mask fit (VMF) test and a user seal check following the manufacturer’s instructions. They found that there was a low N95 VMF pass rate amongst participants.
May 20, 2020 (JAMA)
How Academic Health Systems Can Move Forward Once COVID-19 Wanes
Steven D. Shapiro, Paul B. Rothman
This Viewpoint discusses the role academic health systems can play in response to public health deficiencies identified in the coronavirus disease 2019 (COVID-19) pandemic, including developing early warning systems to identify future outbreaks, addressing community mental health needs more broadly, and working to reduce structural health inequities.
May 19, 2020 (NEJM)
The COVID-19 Pandemic and the Incidence of Acute Myocardial Infarction
Matthew D. Solomon, Edward J. McNulty, Jamal S. Rana et al.
During the Covid-19 pandemic, reports have suggested a decrease in the number of patients presenting to hospitals because of emergency conditions such as acute myocardial infarction. The authors examined this issue using data from a large integrated health care delivery system with 21 medical centers and 255 clinics that provides comprehensive care for more than 4.4 million persons throughout Northern California. They found that the incidence of hospitalization for acute myocardial infarction declined after March 4, 2020, during the Covid-19 pandemic, more than would be expected on the basis of typical seasonal variation alone.
May 18, 2020 (EMJ)
The COVID-19 Conundrum and Cancer - Making Perfect Sense of Imperfect Data
The author reviews current available evidence of COVID-19 and cancer. He discusses the epidemiological data, COVID-19 and cancer therapies and also identifies current gaps in knowledge with regards to COVID-19 and cancer.
May 18, 2020 (JAMA)
Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)
An Unprecedented Partnership for Unprecedented Times
Francis S. Collins, Paul Stoffels
In this viewpoint, the authors describe a partnership involving all sectors of society to work together to address COVID-19.
May 18, 2020 (Medscape)
A Quick Summary of the COVID-19 Literature So Far
Eric A. Meyerowitz, Aaron G. Richterman
In this update, the authors summarise key takeaways regarding COVID-19 covering April 23 to May 5, during which more than 3000 COVID- related papers were published on PubMed and another 766 were released in preprint form. In succinct tables, they summarise the major RCTs on COVID-19 therapeutics and discuss additional therapeutic data from press releases. They also summarise key transmission findings and discuss important learning points on COVID-19.
May 18, 2020 (Science Advances)
Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
Salvatore Di Giorgio, Filippo Martignano, Maria Gabriella Torcia, Giorgio Mattiuz, Silvestro G. Conticello
The authors analyze RNA sequences from bronchoalveolar lavage fluids derived from COVID-19 infected patients. They identify nucleotide changes that may be signatures of RNA editing: Adenosine-to-Inosine changes from ADAR deaminases and Cytosine-to-Uracil changes from APOBEC ones. Their results suggest that both APOBECs and ADARs are involved in Coronavirus genome editing, a process that may shape the fate of both virus and patient.
May 18, 2020 (Nature)
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
Pinto, D., Park, Y., Beltramello, M. et al.
Vaccine and therapeutic discovery efforts are paramount to curb the pandemic spread of this SARS-CoV2 virus. The SARS-CoV-2 spike (S) glycoprotein promotes entry into host cells and is the main target of neutralizing antibodies. Here the authors describe multiple monoclonal antibodies targeting SARS-CoV-2 S identified from memory B cells of an individual who was infected with SARS-CoV in 2003. They explain the potential of using S309- and S309-containing antibody cocktails for prophylaxis in individuals at high risk of exposure or as a post-exposure therapy to limit or treat severe disease.
May 15, 2020 (MMWR Morb Mortal Wkly Rep)
High SARS-CoV-2 Attack Rate Following Exposure at a Choir Practice — Skagit County, Washington, March 2020
Hamner L, Dubbel P, Capron I, et al.
Superspreading events involving SARS-CoV2 have been reported. The authors describe a cluster of infections and their outcomes which occurred after choir practice attended by 61 persons. Citing this event, they emphasise on the importance of physical distancing, including avoiding gathering in large groups, to control spread of COVID-19. Additionally, enhancing community awareness can encourage symptomatic persons and contacts of ill persons to isolate or self-quarantine to prevent ongoing transmission.
May 15, 2020 (JAMA)
Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit
Chiara Sartini, Moreno Tresoldi, Paolo Scarpellini, Andrea Tettamanti, Francesco Carcò, Giovanni Landoni, Alberto Zangrillo
This study, conducted in a single centre in Italy, measured respiratory parameters of 15 non-ICU patients before, during, and after receiving noninvasive ventilation in the prone position and found that it was feasible to do so.
May 14, 2020 (Journal of the Royal Society of Medicine)
The coronavirus pandemic: can we handle such epidemics better?
Peter C Gøtzsche
In this commentary, the author summaries various SARS-CoV2 related publications in the form of a question and answer format and provides a thorough insight on what has happened so far, and where we may be heading.
May 13, 2020 (JAMA)
SARS-CoV-2 Rates in BCG Vaccinated and Unvaccinated Young Adults
Uri Hamiel, Eran Kozer, Ilan Youngster
In this study, the authors collected data on COVID-19 patients from Israel’s National Central Bureau of Statistics. They compared infection rates and proportions with severe COVID-19 disease in 2 similar populations with differing BCG status: individuals born during the 3 years before and 3 years after cessation of the universal BCG vaccine program. They found that BCG vaccination in childhood does not have a protective effect against COVID-19 in adulthood.
May 13, 2020 (Science)
Estimating the burden of SARS-CoV-2 in France
Henrik Salje, Cécile Tran Kiem, Noémie Lefrancq, Noémie Courtejoie, Paolo Bosetti et al.
Despite more than 27,000 confirmed deaths from COVID-19 in France, only about 4.4% of people have been infected. The percentage is still far below the required level of above 50%
May 13, 2020 (JAMA Cardiology)
A Game Plan for the Resumption of Sport and Exercise After Coronavirus Disease 2019 (COVID-19) Infection
Dermot Phelan, Jonathan H. Kim, Eugene H. Chung
Significant cardiac morbidity has been observed among hospitalized patients with COVID-19. Evidenced-based recommendations for return-to-play guidelines are currently limited. Here, the authors provide recommendations that are exclusive to cardiovascular considerations and illustrate with an algorithm.
May 13, 2020 (JAMA Pediatrics)
School Closure During the Coronavirus Disease 2019 (COVID-19) Pandemic
An Effective Intervention at the Global Level?
Susanna Esposito, Nicola Principi
This Viewpoint discusses the effectiveness of school closure as a preventive measure during the coronavirus disease 2019 (COVID-19) pandemic.
May 13, 2020 (JAMA)
Global Effort to Collect Data on Ventilated Patients With COVID-19
This Medical News feature describes an international effort to compile data about ventilated patients with COVID-19.
May 12, 2020 (Int J of Inf Dis)
A dynamic modeling tool for estimating healthcare demand from the COVID19 epidemic and evaluating population-wide interventions
Gabriel Rainisch, Eduardo A. Undurraga, Gerardo Chowell
The authors developed a tool to estimate healthcare demand stemming from the COVID-19 pandemic. They applied this model to three different regions in Chile to illustrate its use and describe their findings in this article. This tool is able to help local authorities examine the impacts of intervention strategies.
May 12, 2020 (Prehospital and Disaster Medicine)
Hospital Emergency Management of Emerging Infectious Disease using Instant Communication Technology
Lin, C., Hsieh, C., & Chi, C.
In this letter to the editor, the authors share three considerations related to using innovative applications to manage the threat of emerging infectious disease.
May 12, 2020 (European Radiology)
Comparison of chest CT findings between COVID-19 pneumonia and other types of viral pneumonia: a two-center retrospective study
Xiao Li, Xu Fang, Yun Bian, Jianping Lu
In this retrospective review, High-resolution CT (HRCT) of the chest was performed on 154 patients with RT-PCR-confirmed COVID-19 pneumonia and compared with 100 patients with other types of viral pneumonia from two hospitals. The authors found that a peripheral distribution, a lesion range > 10 cm, involvement of 5 lobes, presence of hilar and mediastinal lymph node enlargement, and no pleural effusion were significantly associated with COVID-19.
May 12, 2020 (JAMA)
Management of Critically Ill Adults With COVID-19
Jason T. Poston, Bhakti K. Patel, Andrew M. Davis
This JAMA Clinical Guidelines Synopsis summarizes the 2020 Surviving Sepsis Campaign guidelines on the treatment of critically ill adults with coronavirus disease 2019 (COVID-19).
May 12, 2020 (The Lancet)
Retinal findings in patients with COVID-19
Paula M Marinho, Allexya A A Marcos, Andre C Romano, Heloisa Nascimento, Rubens Belfort Jr
Optical coherence tomography (OCT) is a non-invasive imaging technique that is useful for demonstrating subclinical retinal changes in systemic conditions such as diabetes, Parkinson's disease, and Alzheimer's disease, as well as many viral infections. The authors used OCT to evaluate 12 adult patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and describe their findings.
May 12, 2020 (JAMA Internal Medicine)
Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19
Wenhua Liang, Hengrui Liang, Limin Ou, Binfeng Chen, Ailan Chen, Caichen Li, Yimin Li, Weijie Guan, Ling Sang, Jiatao Lu, Yuanda Xu, Guoqiang Chen, Haiyan Guo, Jun Guo, Zisheng Chen, Yi Zhao, Shiyue Li, Nuofu Zhang, Nanshan Zhong, Jianxing He for the China Medical Treatment Expert Group for COVID-19
This cohort study examines the characteristics of patients admitted to the hospital with COVID-19 will need admission to an intensive care unit, mechanical ventilation, or will die, and develops a COVID-19 risk score to predict outcomes.
May 12, 2020 (The Lancet)
Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study
Timothy Roberton, Emily D Carter, Victoria B Chou, Angela R Stegmuller, Bianca D Jackson, Yvonne Tam et al.
In this study, the authors estimate the additional maternal and under-5 child deaths resulting from the potential disruption of health systems and decreased access to food due to the COVID-19 pandemic. They modelled three different scenarios and used the Lives Saved Tool to estimate the additional maternal and under-5 child deaths under each scenario, in low and middle-income countries.
May 11, 2020 (Life Sciences)
A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
Vaishali M. Patil, Shipra Singhal, Neeraj Masand
This review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemists, and pharmacologists actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection.
May 11, 2020 (Infection)
COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients
Georg Harter, Christoph D. Spinner, Julia Roider et al.
This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. A retrospective analysis of anonymized data was carried out including age, gender, HIV-associated parameters, symptoms, and outcome. This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART.
April 30, 2020 (J of Clinical Virology)
Self-collection: An appropriate alternative during the SARS-CoV-2 pandemic
Michael C. Wehrhahn, Jennifer Robson, Suzanne Brown et al.
In this prospective study in Australia, the authors evaluate the reliability of self-collection of nasal and throat swabs for SARS-CoV-2 and other respiratory viruses. They found that there was a high concordance rate between the swabs taken by self collection and by healthcare workers, suggesting a reliable alternative.
April 30, 2020 (JAMA)
Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection
David Baud, Gilbert Greub, Guillaume Favre, et al
This case report describes a pregnant woman with symptomatic coronavirus disease who experienced a second-trimester miscarriage in association with documented placental SARS-CoV-2 infection.
April 30, 3030 (Cell Research)
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals
Cao, Y., Li, L., Xu, M. et al.
The China Metabolic Analytics Project (ChinaMAP) is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China. In this paper, the authors we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP. This study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders.
April 30, 2020 (The Annals of Thoracic Surgery, Preprint)
Assessing the Collateral Damage of the Novel Coronavirus: A Call to Action for the Post-COVID-19 Era
Vervoort D, Luc JGY, Percy E, Hirji S, Lee R
The COVID-19 pandemic has resulted in many elective surgeries being cancelled around the world. This paper explores the contemporary issues impacting healthcare resources during the pandemic and makes recommendations for identifying an appropriate balance of their use to optimize patient care.
April 29, 2020 (Proceedings of the National Academy of Sciences)
Effective treatment of severe COVID-19 patients with tocilizumab
Xiaoling Xu, Mingfeng Han, Tiantian Li, Wei Sun, Dongsheng Wang, Binqing Fu, Yonggang Zhou, Xiaohu Zheng, Yun Yang, Xiuyong Li, Xiaohua Zhang, Aijun Pan, Haiming Wei
Chinese investigators conducted a retrospective, uncontrolled study of 21 patients with severe COVID-19 symptoms (as defined by prespecified criteria) who received treatment with the IL-6 blocker tocilizumab. Within 24 hours of starting tocilizumab therapy, fevers and elevated C-reactive protein levels resolved, and levels of IL-6 and other proinflammatory cytokines declined. Use of supplemental oxygen dropped in 15 patients, oxygen saturation levels stabilized or improved in all patients, the 2 ventilated patients were weaned, and all patients subsequently were discharged alive.
April 29, 2020 (Nature Medicine)
Responding to the hidden pandemic for healthcare workers: stress
Krystal, J.H., McNeil, R.L.
In the COVID-19 pandemic, frontline healthcare workers are having to work under particularly intense stress levels. The author shares how videoconferencing can be harnessed to provide mental-health support, and also addresses ‘tele-health’ fatigue.
April 29, 2020 (Science)
Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China
Juanjuan Zhang, Maria Litvinova, Yuxia Liang, Yan Wang, Wei Wang, Shanlu Zhao, Qianhui Wu, Stefano Merler, Cécile Viboud, Alessandro Vespignani, Marco Ajelli, Hongjie Yu
As transmission intensifies, the interplay between age, contact patterns, social distancing, susceptibility to infection, and COVID-19 dynamics remains unclear. To answer these questions, the authors analyze contact surveys data for Wuhan and Shanghai before and during the outbreak and contact tracing information from Hunan Province. Based on their findings, the authors build a transmission model to study the impact of social distancing and school closure on transmission. They found that social distancing alone, as implemented in China during the outbreak, is sufficient to control COVID-19. While proactive school closures cannot interrupt transmission on their own, they can reduce peak incidence by 40-60% and delay the epidemic.
April 29, 2020 (The Lancet)
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multi centre trial
Yeming Wang, Dingyu Zhang, Prof Guanhua Du, Prof Ronghui Du,
As the search continues for the effective treatment of COVID-19, the authors carried out a double-blinded, placebo-controlled RCT on Remdesivir, a nucleoside analogue prodrug that has inhibitory effects on SARS-CoV2 in vitro. They found that In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits.
April 28, 2020 (Emerg Infect Dis.)
Evaluating the Effectiveness of Social Distancing Interventions to Delay or Flatten the Epidemic Curve of Coronavirus Disease
Laura Matrajt and Tiffany Leung
The authors used a mathematical model to investigate the effectiveness of social distancing interventions carried out in different age groups, over 6 weeks in a mid-sized city. They found that interventions started earlier in the epidemic delay the epidemic curve and interventions started later flatten the epidemic curve. They also highlight that when interventions ended, the epidemic rebounded, suggesting that social distancing can provide crucial time to increase healthcare capacity but must occur in conjunction with testing and contact tracing of all suspected cases to mitigate virus transmission.
April 28, 2020 (Nature)
The race for coronavirus vaccines: a graphical guide
Researchers are trialling different technologies to come up with a vaccine for SARS-CoV2. With the use of infographics, this easy to understand article explains COVID-19 vaccine designs and developments.
April 28, 2020 (American Journal of Obstetrics and Gynaecology)
Maternal Death Due to COVID-19 Disease
Hantoushzadeh S, Shamshirsaz AA, Aleyasin A, Seferovic MD, et al.
In this multi-centre case series in Iran, the authors describe the outcome of 9 pregnant women with laboratory confirmed severe COVID-19 disease during their late 2nd or 3rd trimester.
April 27, 2020 (Nature)
Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals
Liu, Y., Ning, Z., Chen, Y. et al.
This study investigated the aerodynamic nature of SARS-CoV-2 by measuring viral RNA in aerosols in different areas of two Wuhan hospitals during the COVID-19 outbreak in February and March 2020. They found that some medical staff areas initially had high concentrations of viral RNA which were reduced to undetectable levels after implementation of rigorous sanitization procedures. The identification of the virus however does not reflect the infectivity of the virus detected.
April 27, 2020 (The Lancet)
Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study
Qifang Bi, Yongsheng Wu, Shujiang Mei, Chenfei Ye, Xuan Zou, Zhen Zhang et al.
In this retrospective study, data analysis showed that isolation and contact tracing reduce the time during which cases are infectious in the community. The overall impact of isolation and contact tracing, however, is uncertain and highly dependent on the number of asymptomatic cases.
April 27, 2020 (J of Arthroplasty)
Understanding Antibody Testing for COVID-19
David Jacofsky, Emilia M. Jacofsky, Marc Jacofsky
The authors explain the science behind antibody testing, the principle of antibody assays, and interpretation of point-of-care antibody tests.
April 27, 2020 (ID Cases)
SARS-CoV-2 infection in a patient on chronic hydroxychloroquine therapy: Implications for prophylaxis
Khalid M. Dousa, Sharad S. Malavade, Jennifer Furin, Barbara Gripshover, Marjorie Hatszegi, Leila Hojat, Elie Saade, Robert A.Salata
Hydroxychloroquine and chloroquine have been used as treatment for COVID-19 and are being considered as prophylaxis, especially for health care workers who are at high risk. In this case report of a patient who contracted COVID-19 despite being on Hydroxychloroquine, the authors question the role of these medications as preventive therapy.
April 26, 2020 (CellPress, Pre-proof)
Imbalanced host response to SARS-CoV-2 drives development of COVID-19
Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen-Chun Liu, Skyler Uhl, Daisy Hoagland, Rasmus Møller, Tristan X. Jordan, et al.
The transcriptional response to infection with SARS-CoV2 is investigated in vitro (cell lines and primary cells), in vivo (ferrets) and ex vivo (lung tissue from COVID19 patients) and compared to uninfected. They also compare SARS-CoV2 with other respiratory viruses including SARS-CoV1 and IAV. Overall, SARS-CoV2 fails to induce a robust type I/III interferon response even in cells permissive to viral replication, although a subset of ISGs is induced independently of IFN signalling. In contrast, SARS-CoV2 constantly induces the expression of high levels of inflammatory chemokines. Further, they detect similar imbalanced immune response in SARS-CoV-2 infected ferrets and the serum in a cohort of 24 SARS-CoV2+ patients.
April 26, 2020 (J of Clinical Virology)
A RT-PCR assay for the detection of coronaviruses from four genera
Leshan Xiu, Raquel A.Binder, Natalie A. Alarja, Kara Kochek et al.
The authors describe their work in the development of a diagnostic test that is able to detect all coronaviruses from the four main genera. The assay was highly specific and sensitive in detecting CoVs, and performed well on different sample types.
April 25, 2020 (Science of the Total Environment)
Follow-up studies in COVID-19 recovered patients - is it mandatory?
Vellingiri Balachandar, Iyer Mahalaxmi, Mohandevi Subramaniam et al.
The authors recommend a longitudinal study to assess the health status of COVID-19 recovered patients to evaluate any changes in the other organs in human systems. They provide an overview of the multi-system involvement from current data available and also share their recommendations for COVID-19 recovered patients.
April 24, 2020 (JAMA Pediatrics)
Mental health status among children in home confinement during the coronavirus disease 2019 outbreak in Hubei Province, China
Xie X et al.
To examine children's psychological adjustment, researchers surveyed 1784 children in grades 2 to 6 living in Hubei province whose schools had been closed for over a month. Overall, 22.6% of students reported depression symptoms and 18.9% reported anxiety symptoms, both rates are higher than baseline rates reported for children in Asia.
April 24, 2020 (JAMA)
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial
Mayla Gabriela Silva Borba, Fernando Fonseca Almeida Val, Vanderson Souza Sampaio et al.
There is yet to be a specific antiviral therapy recommended for the treatment of COVID-19. However, in-vitro studies have indicated that high doses of chloroquine diphosphate (CQ) has antiviral effects. In this double-blinded RCT, the authors evaluate the safety and efficacy of 2 different doses of CQ and their preliminary findings suggest that higher dosages of CQ should not be recommended for the treatment of severe COVID-19 because of safety concerns regarding QTc interval prolongation and increased lethality.
April 24, 2020 (NEJM)
Mild or moderate COVID-19
Rajesh T. Gandhi, John B. Lynch, and Carlos del Rio
Using a case vignette, the authors provide an excellent overview on COVID-19 covering disease transmission, clinical manifestations, diagnosis, evaluation, management options and infection prevention and control.
April 24, 2020 (Front. Microbiol.)
The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses
Longping V. Tse, Rita M. Meganck, Rachel L. Graham, Ralph S. Baric
Vaccine development targeting coronaviruses is indeed challenging. In this review, the authors summarize the key advancements of current vaccines and antivirals against SARS-CoV and MERS-CoV as well as discuss the challenges and opportunities in the current SARS-CoV-2 crisis. They then advocate the development of a “plug-and-play” platform technologies that could allow quick manufacturing and administration of broad-spectrum countermeasures in an outbreak setting.
April 24, 2020 (JMIR Public Health Surveill.)
Regulation and Trust: 3-Month Follow-up Study on COVID-19 Mortality in 25 European Countries
Atte Oksanen, Markus Kaakinen, Rita Latikka, Iina Savolainen, Nina Savela, Aki Koivula
Although Europe has been greatly affected by the COVID-19 pandemic, there are major country differences in both the spread of the virus and measures taken to stop the virus. In this study, the authors examined country variations of COVID-19 mortality in Europe by analyzing social risk factors explaining the spread of the disease, restrictions and control measures, and institutional trust.
April 23, 2020 (Biomedicine & Pharmacotherapy)
COVID-19: an exploratory randomized controlled trial
Yuhao Zhang, Xiuchao Geng, Yanli Tan et al.
In this paper, the authors systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of SARS-CoV-2 infection.
April 23, 2020 (JAMA)
Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China
Juyi Li, Xiufang Wang, Jian Chen, et al
SARS-CoV2 uses the angiotensin-converting enzyme (ACE) 2 receptor to gain entry into host cells. ACE-inhibitors (ACE-I) and Angiotensin receptor blockers (ARBs) are commonly used in the management of patients with hypertension. This case series seeks to answer the question on whether hypertensive patients on ACE-I or ARB treatment have greater illness severity or increased risk of mortality during hospitalization for COVID-19 infection.
April 23, 2020 (Laboratory Diagnositics)
A SARS-CoV-2 surrogate virus neutralization test (sVNT) based on antibody-mediated blockage of ACE2-spike (RBD) protein-protein interaction
Chee Wah Tan, Wan Ni Chia, Mark I-C Chen et al.
At this time of the COVID-19 pandemic, there is an urgent need for a robust, validated and accessible serological test to detect neutralizing antibodies to SARS-CoV-2. Here, the authors report a validated SARS-CoV-2 surrogate virus neutralization test (sVNT) that is designed to detect total neutralizing antibodies in an isotype- and species-independent manner. They report that their simple and rapid test is based on antibody-mediated blockage of virus-host interaction between the ACE2 receptor protein and the receptor binding domain (RBD) of the viral spike protein.
April 23, 2020 (NEJM)
Ten Weeks to Crush the Curve
Harvey V. Fineberg
In this editorial piece, Dr Fineberg illustrates six steps to mobilize and organize the nation with the aim of defeating COVID-19 by June 2020.
April 22, 2020 (J Clin Nurs.)
Covid-19: Supporting Nurses' Psychological and Mental Health
Jill Maben, Jackie Bridges
Nurses are truly the heart of the healthcare system. In the COVID-19 pandemic, nurses are on the front line of health and social care in the most extreme of circumstances. This article highlights the stressors and challenges nurses face during this time, and provide meures to support them during this difficult time.
April 22, 2020 (Brain Behave Immun.)
Current Status of Potential Therapeutic Candidates for the COVID-19 Crisis
Jiancheng Zhang, Bing Xie, Kenji Hashimoto
There are intensive research and clinical trials underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. In this article, the authors summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and introduce their mechanisms of action, safety, and effectiveness.
April 22, 2020 (Front. Med.)
Thanks to all medical workers fighting against COVID-19
A citizen of Wuhan pens down heartfelt gratitude to all those involved in fighting COVID-19.
April 21, 2020 (The BMJ)
Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study
Zheng Shufa, Fan Jian, Yu Fei, Feng Baihuan, Lou Bin, Zou Qianda et al.
In this retrospective study, the authors evaluated SARS-CoV2 viral loads from various samples at different stages of diseases progression in COVID-19 positive patients and found that the duration of SARS-CoV2 is significantly longer in stool samples than in respiratory and serum samples. They also conclude that the virus persists longer with higher load and peaks later in the respiratory tissues of patients with severe disease.
April 21, 2020 (The Lancet)
Connecting clusters of COVID-19: an epidemiological and serological investigation
Sarah Ee Fang Yong, Danielle Elizabeth Anderson, Wycliffe E Wei, Junxiong Pang, Wan Ni Chia, Chee Wah Tan
Identification of the source of COVID-19 infections and elucidating the chain of disease transmission are crucial for effective disease containment. The authors describe an epidemiological investigation carried out in Singapore that established links between three clusters of COVID-19, with the use of SARS-CoV-2 serological assays.
April 21, 2020 (The Lancet)
Ethnicity and COVID-19: an urgent public health research priority
Manish Pareek, Mansoor N Bangash, Nilesh Pareek, Daniel Pan, Shirley Sze, Jatinder S Minhas et al.
The authors noticed that early reports from China and Italy showed a striking difference in mortality indicating that ethnicity might affect disease outcome. They reviewed published papers and national surveillance reports on notifications and outcomes of COVID-19 to ascertain ethnicity data reporting patterns, associations, and outcomes. They found that none of the ten highest COVID-19 case-notifying countries reported data related to ethnicity.
April 20, 2020 (Cell, Preprint)
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
Ziegler, C.G.K., Allon, S.J., Nyquist, S.K., et al https://doi.org/10.1016/j.cell.2020.04.035
In this paper, the authors investigate the cell subsets targeted by SARS-CoV-2 in host tissues, and the factors that regulate ACE2 expression. Based on human and animal single-cell RNA-sequencing (scRNA-seq) datasets across health and disease, they identified ACE2 and TMPRSS2 co-expressing cells within lung type II pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. They discover that ACE2 is a human interferon-stimulated gene (ISG) in vitro using airway epithelial cells, and extend their findings to in vivo viral infections.
April 20, 2020 (Eur J of Radiology)
Radiology department strategies to protect Radiologic Technologists against COVID19: experience from Wuhan
Yanjie Zhao, Chunlin Xiang, Shaofang Wang, Chengdong Peng, Qian Zou, Junwu Hu
Computed Tomography (CT) of the chest has become an important investigative tool in COVID-19. As such, radiologic technologists who conduct this procedure for the infected patients are at a high risk of contracting the disease themselves. The authors share systematic strategies encompassing personnel arrangements, environmental modification, protection levels and configurations, radiological imaging (CT and radiography), and disinfection methods to combat COVID-19 in the radiology department.
April 20, 2020 (Eur J Clin Invest.)
COVID-19 Diagnosis Does Not Rule Out Other Concomitant Diseases
Alberto Borghetti, Arturo Ciccullo, Elena Visconti, Enrica Tamburrini, Simona Di Giambenedetto
Although in this pandemic phase, it must not be forgotten that the diagnosis of COVID-19 does not imply the exclusion of other concomitant diseases. In this letter, the authors share a case vignette highlighting the importance of evaluating patients as a whole, and the need for clinicians to maintain a high level of attention when evaluating patients with COVID-19.
April 17, 2020 (The Lancet)
Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study
Prof Benjamin J Cowling, Sheikh Taslim Ali, Tiffany W Y Ng, Tim K Tsan, Julian C M Li, Peng Wu… Prof Gabriel M Leung
The authors examined the effect of these interventions and behavioural changes of the public on the incidence of COVID-19. When Peng Wu at the University of Hong Kong and her colleagues surveyed residents in early March, 99% said they wore a mask in public and 85% said they avoided crowds.
April 17, 2020 (JAMA)
Educate, Amplify, and Focus to Address COVID-19 Misinformation
Valerie A. Earnshaw, Ingrid T. Katz
Technology has made information readily available to all. The downside to this is that there is a growing surge of misinformation which needs to be urgently addressed. The authors emphasize on the role of health care professionals in dispelling misinformation.
April 17, 2020 (JAMA)
The Promise and Peril of Antibody Testing for COVID-19
There are recommendations for health-care providers to use serological tests to detect antibodies to SARS-CoV-2 to help identify people who may have been exposed to the virus or have recovered from the COVID-19 infection. This article discusses how antibody tests should—and should not—be used during the SARS-CoV-2 pandemic.
April 17, 2020 (Stem Cells and Development, Preprint)
Stem Cell-Based Therapy for Coronavirus Diseases 2019
Rober Chunhua Zhao
Currently, there is still no specific effective antiviral treatment for COVID-19. It is also known that the immune response plays a vital part in the course of this disease. In this article, the author describes basic research and ongoing clinical trials on mesenchymal stem cells (MSCs) and discusses it’s potential use as an effective treatment for patients with COVID-19.
April 17, 2020 (Asian Journal of Psychiatry)
Mental health problems faced by healthcare workers due to the COVID-19 pandemic–A review
Mamidipalli Sai Spoorthy, Sree, Karthik Pratapa, Supriya Mahant
This review was done to conduct a systematic appraisal of studies on Mental health problems faced by healthcare workers due to the COVID-19 pandemic. The review showed that several socio-demographic variables like gender, profession, age, place of work, department of work were associated with increased stress, anxiety, depressive symptoms and insomnia in HCW.
April 16, 2020 (JAMA)
Finding Ways to Reduce Coronavirus Exposure During Dialysis
This Medical News Feature examines what hemodialysis centers are doing to protect their high-risk patients from COVID-19.
April 16, 2020 (JAMA)
Meeting the Care Needs of Older Adults Isolated at Home During the COVID-19 Pandemic
Steinman MA, Perry L, Perissinotto CM.
The COVID19 pandemic has resulted in the need for social distancing and isolation. This can adversely affect the older adults. This viewpoint stresses the importance of recognising the challenges created by COVID-19 and addresses how clinicians can help reduce these potentially negative effects.
April 16, 2020 (Baylor University Medical Centre Proceedings)
SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill
Amir Kazory, Claudio Ronco & Peter A. McCullough
A subset of patients with COVID-19 develop a more severe form of the diseases characterized by expanding pulmonary lesions, sepsis, acute respiratory distress syndrome, and respiratory failure. Due to lack of data on treatment strategies specific to this group, current management of the critically ill is extrapolated and customized to their clinical needs. The article calls attention to fluid stewardship in the critically ill patients with COVID-19 by judiciously applying the evidence-based resuscitation principles to their specific clinical features such as high rates of cardiac injury. This strategy is likely to help reduce potential complications.
April 15, 2020 (J Med Virol.)
Possibly Critical Role of Wearing Masks in General Population in Controlling COVID-19
Guangshu Han, Yi-Hua Zhou
The authors summarise existing evidence on the spread of COVID-19 and the use of masks in prevention. They advocate the need for wearing masks in the general population to control COVID-19.
April 15, 2020 (Nature Medicine)
Temporal dynamics in viral shedding and transmissibility of COVID-19
He, X., Lau, E.H.Y., Wu, P. et al.
The authors report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 infector–infectee transmission pairs. Their findings infer that infectiousness peaked on or before symptom onset.
April 14, 2020 (New Microbes and New Infections)
Review on the global epidemiological situation and the efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19
S. Saqrane, M.A. El Mhammedi
The authors summarise the current epidemiological situation of the coronavirus outbreak as well as current information available on Hydroxycholoroquine as potential treatment for the disease.
April 14, 2020 (Viruses)
Molecular Investigation of SARS–CoV-2 Proteins and Their Interactions with Antiviral Drugs
Paolo Calligari, Sara Bobone, Giorgio Ricci, Alessio Bocedi
With the vast number of people affected by SARS-CoV2, and with no vaccination available, there is an urgent need to find effective treatment strategies. In this article, the Italians share with us their work on using the molecular docking approach to analyze the affinity between different viral proteins and several inhibitors, originally developed for other viral infections. Their data show that, in some cases, a relevant binding can be detected, supporting the hypothesis to develop new antiviral agents against COVID-19, on the basis of already established therapies.
April 14, 2020 (Science)
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period
Stephen M. Kissler, Christine Tedijanto, Edward Goldstein, Yonatan H. Grad, Marc Lipsitch
Yonatan Grad, Marc Lipsitch and their colleagues at the Harvard T.H. Chan School of Public Health in Boston, Massachusetts, modelled the spread of coronaviruses in places that have temperate climates, such as the United States. The results helped the team to predict the spread of SARS-CoV-2, the coronavirus that causes COVID-19.
April 14, 2020 (MedRxiv, Preprint)
Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial
Wei Tang, Zhujun Cao, Mingfeng Han, Qing Xie et al.
In this multicenter, open label, randomised control trial, the authors set out to assess the efficacy and safety of hydroxychloroquine (HCQ) plus standard-of-care (SOC) compared with SOC alone in adult patients with COVID-19.
April 14, 2020 (Intensive and Critical Care Nursing)
End-of-life decisions and care in the midst of a global coronavirus (COVID-19) pandemic
The author broaches a very important aspect of medicine in this article discussing end-of-life decisions and care, as well as bereavement support amidst the COVID-19 pandemic
April 14, 2020 (Science)
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period
Stephen M. Kissler, Christine Tedijanto, Edward Goldstein, Yonatan H. Grad, Marc Lipsitch.
The authors highlight the urgent need to understand the future of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) transmission. In this article, they used estimates of seasonality, immunity, and cross-immunity for betacoronaviruses OC43 and HKU1 from time series data from the USA to inform a model of SARS-CoV-2 transmission.
April 13, 2020 (J of Medical Virology)
Coronavirus disease 2019: new things to know!
Souheil Zayet, Kadiane‐Oussou N'dri Juliette, Pierre‐Yves Royer, Lynda Toko, Vincent Gendrin, Timothee Klopfenstein
In this article, the authors report their findings from a retrospective study carried out in a single centre. They highlight clinical features that are not just confined to the respiratory tract.
April 13, 2020 (JAMA)
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) A Review
James M. Sanders, Marguerite L. Monogue, Tomasz Z. Jodlowski et al
In this review, the authors summarise an extensive literature review on pharmacologic treatments for COVID-19. They discuss all available pharmacological options at present, and share current clinical treatment experience and recommendations.
April 12, 2020 (Wiley Connections)
We urgently need guidelines for managing COVID‐19 in children with comorbidities
In this letter, Dr Dayal summarises current evidence available for the management of COVID-19 in children and identifies the gaps in research.
April 11, 2020 (The Lancet)
Regulators split on antimalarials for COVID-19
The use of antimalarials such as chloroquine and hydroxychloroquine in the treatment of COVID-19 has sparked much debate. In this article, the author discusses the various viewpoints of international regulators regarding this topic.
April 10, 2020 (J R Coll Physicians Edinb)
Have we found the panacea to COVID-19 with remdesivir, an old but newly packaged drug?
Abdul Malik Mohamed Thalha, Yeong Yeh Lee, Alwi Besari, Sharifah Faridah Syed Omar
In this piece, the authors share their opinion on the use of Remdisivir for the treatment of COVID-19. They summarise the current available evidence on Remdisivir and are of the opinion that whilst they are studies suggesting clinical benefit, remdesivir is not a panacea.
April 10, 2020 (J of Infection)
Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis
Leiwen Fu, Bingyi Wang, Tanwei Yuan, Xiaoting Chen, Yunlong Ao, Thomas Fitzpatrick et al.
The authors performed an extensive systematic review and meta-analysis to provide a comprehensive characterisation of COVID-19 to better inform efforts to treat and control the current outbreak. They reviewed studies from 4 different databases and reviewed for methodological quality prior to selecting 43 COVID-19 studies involving a total of 3600 patients from across the world. They performed extensive data analysis and also assessed heterogeneity between studies. They summarise the clinical signs, risk factors, laboratory and chest CT findings, complications, and treatments of COVID-19. The authors found that the majority of COVID-19 cases are symptomatic with a moderate case fatality rate (CFR). Additionally, patients living in Wuhan, older patients, and those with medical co-morbidities tend to have more severe clinical symptoms and higher CFR.
April 10, 2020 (JAMA)
Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China
Pan A, Liu L, Wang C, et al.
In this cohort study, the authors evaluate the association of public health interventions with the epidemiological features of the COVID-19 outbreak in Wuhan by 5 periods according to key events and interventions. They included 32 583 patients with laboratory-confirmed COVID-19 in Wuhan from December 8, 2019, through March 8, 2020. The interventions include cordons sanitaire, traffic restriction, social distancing, home quarantine, centralized quarantine, and universal symptom survey. The found that these interventions were temporally associated with reduced effective reproduction number of SARS-CoV-2 (secondary transmission) and the number of confirmed cases per day across age groups, sex, and geographic regions.
April 10, 2020 (Emerg Infect Dis., Early Release)
Aerosol and Surface Distribution of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospital Wards, Wuhan, China, 2020
Guo Z-D, Wang Z-Y, Zhang S-F, Li X, Li L, Li C, et al.
The main transmission routes for SARS-CoV-2 are respiratory droplets and close contact. It is important to know the extent of environmental contamination of SARS-CoV-2 in COVID-19 wards to improve safety practices for health care workers, and to also address public concerns regarding transmission. In this study, air and surface samples were taken from intensive care units and general wards of two hospitals treating COVID-19 patients in Wuhan.
April 10, 2020 (JAMA)
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China
Mao L, Jin H, Wang M, et al.
In this retrospective study, the authors take a look at neurological manifestations of patients with COVID-19. They also highlight the importance to consider the diagnosis of COVID-19 in patients with neurological manifestations.
April 10, 2020 (Journal of Infection 2020)
Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside Wuhan and characteristics of young patients with COVID-19: a prospective contact-tracing study.
L. Huang, X. Zhang and X. Zhang et al.
This is a contact-tracing study of a Covid-19 patient in Feidong province, China, returning from Wuhan. His close contacts, during both pre-symptomatic and symptomatic periods, were traced and followed-up to determine any. The authors described the type, and significance of contacts, and identified amongst them those that went on to develop Covid-19 and vice-versa.
April 10, 2020. (CDC Mortality and Morbidity Weekly Report)
Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020.
Wei WE, Li Z, Chiew CJ, Yong SE, Toh MP, Lee VJ
This is a CDC report with a summary of 8 separate clusters in Singapore, that demonstrated pre-symptomatic transmissions of Covid-19 cases. The reported transmissions ranged between 1-3 days before the source started developing symptoms. The cases were either from direct respiratory droplets or indirect transmission via environmental or fomite contamination.
April 10, 2020 (J of Autoimmunity)
Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
Bingwen Liu, Min Li, Zhiguang Zhou, Xuan Guan, YuFei Xiang
Cytokine release syndrome has been implicated as the cause of severe illness in COVID-19. Here, the authors explain the pathogenesis of CRS not only in COVID-19, but also in SARS and MERS, comparing the three. They also summarize the existing therapies for CRS. Additionally, they discuss the use of interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS, including factors that should be taken into consideration for its clinical application.
April 9, 2020 (Nature)
Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Jin, Z., Du, X., Xu, Y. et al.
Mpro is an important coronavirus enzyme, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. The authors describe the structure of Mpro and their mechanism of discovery of its inhibitors. This could lead to the rapid discovery of drug leads with clinical potential.
April 9, 2020 (Eur J Preventive Cardiology)
Physical inactivity and cardiovascular disease at the time of coronavirus disease 2019 (COVID-19)
Giuseppe Lippi, Brandon M Henry, Fabian Sanchis-Gomar.
During quarantine, staying active and maintaining a physical exercise routine is essential for mental and physical health. The authors encourage authorities to include clear exceptions for physical activity such as allowing for safe performance of outdoor physical activities (e.g. walking or running where an adequate interpersonal distance can be maintained), and thus prevent unfavourable cardiovascular diseases.
April 8, 2020 (BMC Med)
Optimising strategies to address mental ill-health in doctors and medical students: ‘Care Under Pressure’ realist review and implementation guidance
Carrieri, D., Mattick, K., Pearson, M. et al.
The authors suggest that successful and effective interventions to tackle doctors’ and students’ mental ill-health are likely to be multidimensional and multilevel and involve multiple stakeholders. The review indicates that evaluating and improving existing interventions is likely to be more effective than developing new ones.
April 8, 2020 (Nature Biomed Eng)
This must-read editorial mentions that the world needs mass at-home serological testing for antibodies elicited by SARS-CoV-2, and rapid and frequent point-of-care testing for the presence of the virus’ RNA in selected populations.
April 8, 2020 (Clinical Microbiology and Infection)
Challenges and issues about organizing a hospital to respond to the COVID-19 outbreak: experience from a French reference centre
N. Peiffer-Smadja, J.-C. Lucet, G. Bendjelloul et al.
In order to provide data on the resilience of health systems during the COVID-19 pandemic, the authors describe, at the hospital level, the key elements of the response to COVID-19, including the challenges and issues to anticipate following the experience of their centre, one of the largest hospital system in Europe.
April 7, 2020 (Maturitas)
COVID-19: The forgotten priorities of the pandemic
Cristina Mesa Vieira, Oscar H. Franco, Carlos Gomez Restrepo, Thomas Abel
This article has been awarded the Editor’s choice for the June edition of Maturitas. In the paper, the authors describe some implications of social distancing that can be detrimental to people’s mental health, especially of those who do not have an extensive support network.
April 7, 2020 (MedRxiv, pre print)
Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection
Cristina Menni, Ana Valdes, Maxim B Freydin, … Tim Spector
The authors perform a community survey to investigate the prevalence of loss of smell and taste among COVID-19 diagnosed individuals and to identify the combination of symptoms, besides loss of smell and taste, that most likely corresponds to a positive COVID-19 diagnosis in non-severe cases.
April 6, 2020 (PNAS)
Effectiveness of convalescent plasma therapy in severe COVID-19 patients
Kai Duan, Bende Liu, Cesheng Li, et al.
In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospectively for convalescent plasma (CP) treatment. Their preliminary results indicate that CP can serve as a promising rescue option for severe COVID-19 patients.
April 4, 2020 (J of Hospital Infection)
Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong
Wong SC-Y, Kwong RT-S, Wu TC, Chan JWM, Chu MY, Lee SY, Wong HY, Lung DC
In this contact investigation revolving around one patient, the authors findings suggest that SARS-CoV-2 is not spread by an airborne route, and nosocomial transmissions can be prevented through vigilant basic infection control measures, including wearing of surgical masks, hand and environmental hygiene.
April 3, 2020 (Asian J of Psychiatry)
Issues relevant to mental health promotion in frontline health care providers managing quarantined/isolated COVID19 patients
Ritin Mohindra, Ravaki R, Vikas Suri et al.
The authors conducted interviews with health care providers managing COVID-19 patients to find out the perceived motivations influencing morale. They identified three themes: positive Motivational factors (that need to be strengthened), Negatives, frustrations associated with patient care, and personal fears and annoyances experienced by doctors. They present their findings with a view to disseminate so that hospitals facing or preparing for COVID-19 can factor in these issues.
April 3, 2020 (IJID 2020)
The enlightenment from two cases of asymptomatic infection with SARS-CoV-2: is it safe after 14 days of isolation? International Journal of Infectious Diseases
Zhi-Qun Mao, Ren Wan, Li-Yi He, Yue-Chun Hu, Wei Chen.
This is a case report of 2 asymptomatic infections in China, which showed persistence of SARS-CoV2 genome beyond 14 days of isolation. Both received antiviral treatments but remained asymptomatic throughout the period. Serial chest radiographs remained negative. They both achieved 1st negative swab on Day 19 and Day 22 of contact, and 2nd negative swabs 2 days later and discharged. There were no records of infections to close contacts.
April 2, 2020 (Infect Control Hosp Epidemiol.)
Potential impact of contaminated bronchoscopes on novel coronavirus disease (COVID-19) patients
Ofstead CL, et al.
In this letter to the editor, the authors bring up the possibility of bronchoscopy-associated transmission of COVID-19 given previous evidence of bronchoscopy related nosocomial outbreaks of other pathogens.
April 2, 2020 (Nature)
Masks could cut spread of COVID-19 virus
To mask or not to mask, the effectiveness of masking
April 1, 2020 (J. Zhejiang Univ. Sci. B)
Dialectical behavior therapy-based psychological intervention for woman in late pregnancy and early postpartum suffering from COVID-19: a case report
Huang, J., Zhou, X., Lu, S. et al.
The authors share their experience using dialectical behaviour therapy-based psychological intervention involving mindfulness training, relaxation exercise for regulating negative emotions, distress tolerance skills, as well as interpersonal skills to share distress and gain support on a pregnant COVID-19 positive patient.
March 29, 2020
The FDA has released a FACT SHEET FOR HEALTHCARE PERSONNEL
Battelle Decontamination System for Decontaminating Compatible N95 Respirators
March 28, 2020 (J Microbiol Biotechnol)
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19)
Ahn DG, Shin HJ, Kim MH, Lee S, Kim HS, Myoung J, Kim BT, Kim SJ.
March 28, 2020 (MedRxiv - Preprint)
Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study
Aaron Miller, Mac Josh Reandelar, Kimberly Fasciglione, Violeta Roumenova, Yan Li, Gonzalo H Otazu
COVID-19 is a global pandemic, with varying impact amongst different countries. The authors propose that national differences in COVID-19 impact could be partially explained by the different national policies respect to Bacillus Calmette-Guerin (BCG) childhood vaccination. BCG vaccination has been reported to offer broad protection to respiratory infections. The authors compared a large number of countries BCG vaccination policies with the morbidity and mortality for COVID-19 and found that countries without universal policies of BCG vaccination are more severely affected.
March 27, 2020 (Diagn Interv Radiol)
Interventional radiology and COVID-19: evidence-based measures to limit transmission
Chandy PE, Nasir MU, Srinivasan S, Klass D, Nicolaou S, Babu SB.
The authors put forth an all-encompassing review of infection control measures that cover the dynamics of patient care and staff protocols to limit transmission of COVID-19 in an interventional radiology department.
March 26, 2020 (JAMA)
Covid-19 — Navigating the Uncharted
A must-read editorial by Dr. A Fauci, the National Institute of Allergy and Infectious Diseases
March 25, 2020 (European Journal of Radiology)
Diagnosis of the coronavirus disease (COVID-19): rRT-PCR or CT
Researchers explored the diagnostic value of CT and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia
March 24, 2020 (Clinical and Translational Radiation Oncology)
COVID-19: Global radiation oncology’s targeted response for pandemic preparedness
Richard Simcock, Toms Vengaloor Thomas, Christopher Estes, Andrea R. Filippi, Matthew S. Katz, Ian J. Pereira, Hina Saeed
As the global COVID-19 pandemic escalates there is a need within radiation oncology to work to support patients in the best way possible. Measures are required to reduce infection spread between patients and within the workforce. The #radonc community held an urgent online journal club on Twitter in March 2020 to discuss these issues and create some consensus on crucial next steps. This document summarises these discussions around themes of infection prevention, rationalisation of workload and working practice in the presence of infection.
March 23, 2020 (The Lancet)
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study
Kelvin Kai-WangTo, Owen Tak-YinTsang, Wai-Shing Leung, Anthony RaymondTam, Tak-Chiu Wu David Christopher Lung, Cyril Chik-Yan Yip, Jian-Piao Cai, …Kwok-Yung Yuen
The more viral RNA detected in a person’s body, the more they excrete when coughing or sneezing. The authors say that the high levels of SARS-CoV-2 particles detected at the onset of symptoms suggest that the virus can be transmitted easily between people, even when symptoms are relatively mild. The results are consistent with another study by L. Zou et al. (shared below).
March 20, 2020 (Int. J of Inf. Diseases)
COVID-19: Four Paediatric Cases in Malaysia
K.C. See, S.M. Liew, David C.E. Ng , E.L. Chew , E.M. Khoo , C.H. Sam, D. Sheena, Z. Zahilah Filzah, S.Y. Chin, P.Y. Lee, L.P. Tan, Z. Farah Najwa et al.
The authors briefly report 4 paediatric cases of confirmed COVID-19 in Malaysia. They discuss the major issues regarding the care of infected children. Firstly, the quarantine of an infected child with a parent who tested negative was an ethical dilemma. Secondly, oropharyngeal and nasal swabs in children were at risk of false negative results. These issues have implications for infection control. They conclude that there is a need for clearer guidelines for child quarantine and testing methods in the management of COVID-19 in children.
March 20, 2020 (Clinical Infectious Diseases)
Epidemiological and clinical predictors of COVID-19
The authors conclude that clinical and laboratory data could identify individuals at high risk of COVID-19 and enable prioritization of PCR-testing and containment efforts. Basic laboratory test results are crucial to prediction models.
March 19, 2020 (J of Reproductive Immunology)
Why are pregnant women susceptible to COVID-19? An immunological viewpoint
Hong Liu, Li-Ling Wang, Si-Jia Zhao, Joanne Kwak-Kim, Gil Mor, Ai-Hua Liao
The COVID-19 may alter the maternal symmetrical and local immune responses, and affect the well-being of mothers and infants. Pregnant women are more susceptible to respiratory pathogens; hence, they may be more susceptible to SARS-CoV-2 than the general population. Here, the authors focused on the immunological factor of the susceptibility of pregnant women to COVID-19 and the potential damages to mother and fetus.
March 19, 2020 (NEJM)
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
Lirong Zou, Feng Ruan, Mingxing Huang, Lijun Liang, Huitao HUang, Zhongsi Hong, Jianxiang Yu, Jinyu Xia, Qianfang Guo, Hui-Ling Yen, Jie Wu
The authors analyse the SARS-CoV2 virus from nose and throat swabs from 18 people with COVID-19. The concentrations of viral RNA in the 17 symptomatic patients were similar to that in the one asymptomatic patient.
March 3, 2020 (Journal of Zhejiang University SCIENCE B)
Clinical value of the emergency department in screening and diagnosis of coronavirus disease 2019 in China
Qin Zhang, Jian Pan, Min-xing Zhao, Yuan-qiang Lu
The emergency department shoulders a heavy responsibility of screening COVID-19 while treating all kinds of other non-communicable acute and critical diseases. In this article, the authors retrospectively analyze four representative cases of COVID-19 that were recently screened and diagnosed in their emergency department. These cases demonstrate that the emergency department has irreplaceable clinical value in the accurate screening and diagnosis of COVID-19.
February 26, 2020 (J of Autoimmunity)
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak
Hussin A. Rothan, Siddappa N. Byrareddy
In this review, the authors highlight the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of COVID-19.